Booting Earth Optimization System
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Spironolactone
Treatment for Acne
Typical Dosage: 25mg to 100mg daily
Effectiveness
62%
Safety Score
60%
Clinical Trials
3
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
25mg to 100mg daily
Time to Effect
2-3 months
Treatment Duration
Long-term (years)
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$300
Side Effect Mgmt:$20
Total Annual:$520
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$800
Cost per Remission
$1,155.56
Spironolactone Outcomes
for Acne
Efficacy Outcomes
Overall Effectiveness
+62%
Response Rate
+65%
Remission Rate
+45%
Common Side Effects
Menstrual irregularities
+20%
Breast tenderness
+15%
Dizziness/lightheadedness
+10%
Fatigue
+7%
Hyperkalemia
+2%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for Spironolactone in Acne
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
NCT04582383ACTIVE NOT RECRUITINGPHASE4
350 participants
INTERVENTIONAL
Fort Smith, United States +17 more
Started: Mar 30, 2022
Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study
NCT07473895NOT YET RECRUITINGPHASE2
40 participants
INTERVENTIONAL
Asyut, Egypt
Started: Apr 1, 2026
Completed Clinical Trials
1 completed trial for Spironolactone in Acne
Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.
NCT03334682COMPLETEDPHASE3
158 participants
INTERVENTIONAL
Brest, France +8 more
Started: Jan 31, 2018