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Antibiotic Therapy (for uncomplicated appendicitis)
Treatment for Appendicitis
Typical Dosage: Ertapenem 1g IV daily for 3-5 days, then oral equivalent for 5-7 days; or Cefotaxime 1g IV q8h + Metronidazole 500mg IV q8h for 3-5 days, then oral Amoxicillin-Clavulanate for 5-7 days.
Effectiveness
75%
Safety Score
70%
Clinical Trials
13
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Ertapenem 1g IV daily for 3-5 days, then oral equivalent for 5-7 days; or Cefotaxime 1g IV q8h + Metronidazole 500mg IV q8h for 3-5 days, then oral Amoxicillin-Clavulanate for 5-7 days.
Time to Effect
24-48 hours for symptom improvement
Treatment Duration
7-14 days (antibiotics), up to 1 year observation for recurrence
Evidence Quality
MODERATENumber Needed to Treat (NNT)
1.3(Treat 1.3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$1,000
Side Effect Mgmt:$100
Total Annual:$3,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$30,000/QALY
QALYs Gained
-0.02
Outcome-Based Costs
Cost per Responder
$4,667
Cost per Remission
$4,667
Comparison vs Laparoscopic Appendectomy
Cost Difference
$-16,500/year
Less expensive
QALY Difference
-0.02 QALYs
Worse outcomes
Dominance
No dominance
Antibiotic Therapy (for uncomplicated appendicitis) Outcomes
for Appendicitis
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+75%
Common Side Effects
Diarrhea
+10%
Nausea/vomiting
+7%
Allergic reaction
+3%
C. difficile infection
+0.5%
Treatment failure requiring appendectomy
+25%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
4 active trials recruiting for Antibiotic Therapy (for uncomplicated appendicitis) in Appendicitis
Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis
NCT03236961ACTIVE NOT RECRUITINGNA
552 participants
INTERVENTIONAL
Turku, Finland
Started: Apr 3, 2017
Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis
NCT03234296ENROLLING BY INVITATIONNA
147 participants
INTERVENTIONAL
Turku, Finland
Started: Aug 9, 2017
Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis
NCT06210269NOT YET RECRUITINGNA
498 participants
INTERVENTIONAL
Jyväskylä, Finland +8 more
Started: Jan 1, 2024
Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children
NCT07587450NOT YET RECRUITINGPHASE3
724 participants
INTERVENTIONAL
Bordeaux, France +9 more
Started: Sep 1, 2026
Completed Clinical Trials
5 completed trials for Antibiotic Therapy (for uncomplicated appendicitis) in Appendicitis
Appendectomy Versus Conservative Treatment for Uncomplicated Acute Appendicitis
NCT03080103COMPLETED
300 participants
OBSERVATIONAL
Muravera, Italy +6 more
Started: Jun 1, 2017
Acute Appendicitis: Active Observation With and Without Antibiotics
NCT03985514COMPLETEDPHASE4
126 participants
INTERVENTIONAL
Gothenburg, Sweden
Started: May 15, 2018
Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.
NCT04803422COMPLETEDNA
3.19K participants
INTERVENTIONAL
Slagelse, Denmark +1 more
Started: Apr 1, 2021
Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children
NCT02991937COMPLETEDPHASE4
39 participants
INTERVENTIONAL
New York, United States
Started: Dec 1, 2016
Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis
NCT02447224COMPLETEDEARLY_PHASE1
30 participants
INTERVENTIONAL
Sylmar, United States
Started: Mar 1, 2015