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Amiodarone
Treatment for Atrial Fibrillation
Typical Dosage: Loading dose 600-1200 mg/day for 1-2 weeks, then 100-400 mg/day maintenance
Effectiveness
70%
Safety Score
50%
Clinical Trials
150
Participants
40K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
Loading dose 600-1200 mg/day for 1-2 weeks, then 100-400 mg/day maintenance
Time to Effect
1-3 weeks
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
5(Treat 5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$1,500
Side Effect Mgmt:$1,000
Total Annual:$2,700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$45,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$4,500
Cost per Remission
$5,400
Comparison vs Metoprolol
Cost Difference
+$500/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Amiodarone Outcomes
for Atrial Fibrillation
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Remission Rate
+50%
Common Side Effects
Thyroid dysfunction
+17%
Liver dysfunction
+17%
Corneal microdeposits
+90%
Pulmonary toxicity
+7%
Gastrointestinal upset
+12%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for Amiodarone in Atrial Fibrillation
Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
NCT01422148NOT YET RECRUITINGPHASE2
60 participants
INTERVENTIONAL
Melrose, United States
Started: Jul 1, 2025
Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation
NCT07273994RECRUITINGPHASE4
312 participants
INTERVENTIONAL
Barcelona, Spain
Started: Nov 1, 2025
Completed Clinical Trials
8 completed trials for Amiodarone in Atrial Fibrillation
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
NCT01173809COMPLETEDPHASE3
176 participants
INTERVENTIONAL
Austin, United States
Started: Oct 1, 2010
Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response
NCT06262932COMPLETEDPHASE4
24 participants
INTERVENTIONAL
Bangkok, Thailand
Started: May 1, 2024
Time-dependent Amiodarone Treatment in Atrial Fibrillation
NCT03432663COMPLETEDPHASE4
60 participants
INTERVENTIONAL
Monterrey, Mexico
Started: Aug 1, 2008
Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft
NCT00654290COMPLETEDNA
240 participants
INTERVENTIONAL
Shiraz, Iran
Started: Mar 1, 2007
Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
NCT00127712COMPLETEDPHASE4
130 participants
INTERVENTIONAL
Indianapolis, United States
Started: Sep 1, 2004
Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients With Atrial Tachyarrhythmias
NCT03413150COMPLETED
80 participants
OBSERVATIONAL
Started: Jan 1, 2007
Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit
NCT01461733COMPLETEDPHASE4
25 participants
INTERVENTIONAL
Started: Jul 1, 2007
Amiodarone to Prevent Post-Operative Arrhythmias
NCT00251706COMPLETEDPHASE3
600 participants
INTERVENTIONAL
Calgary, Canada
Started: Feb 1, 1999
Showing 20 of 160 total trials