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Olanzapine
Treatment for Bipolar Disorder
Typical Dosage: 5-20mg daily
Effectiveness
87%
Safety Score
40%
Clinical Trials
84
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
5-20mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$1,100
Side Effect Mgmt:$600
Total Annual:$2,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$70,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$3,384.6
Cost per Remission
$4,888.9
Comparison vs Quetiapine
Cost Difference
+$100/year
More expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
Olanzapine Outcomes
for Bipolar Disorder
Efficacy Outcomes
Overall Effectiveness
+87%
Response Rate
+65%
Remission Rate
+45%
Common Side Effects
Weight gain
+50%
Sedation
+40%
Dry mouth
+15%
Metabolic syndrome
+25%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for Olanzapine in Bipolar Disorder
A Study of Olanzapine in Participants With Bipolar Disorder.
NCT07263191RECRUITING
3K participants
OBSERVATIONAL
Seongnam, South Korea
Started: Oct 30, 2025
Completed Clinical Trials
16 completed trials for Olanzapine in Bipolar Disorder
Short Term Rescue Study of Olanzapine
NCT00186017COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Stanford, United States
Started: Jul 1, 2005
Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder
NCT01864551COMPLETEDPHASE4
60 participants
INTERVENTIONAL
Taipei, Taiwan
Started: Aug 1, 2008
Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression
NCT01303601COMPLETEDPHASE4
68 participants
INTERVENTIONAL
Shenyang, China
Started: Jan 1, 2009
Optimal Length of Treatment Continuation With Olanzapine After Remission of Manic or Mixed Episode
NCT00191997COMPLETEDPHASE4
180 participants
INTERVENTIONAL
Barcelona, Spain +10 more
Started: Oct 1, 2004
40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857)
NCT00159783COMPLETEDPHASE3
218 participants
INTERVENTIONAL
Started: Jul 1, 2005
Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified(OL Study)
NCT02287259COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Chiba, Japan
Started: Nov 1, 2014
Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder
NCT00034580COMPLETEDPHASE4
326 participants
INTERVENTIONAL
Berkley, United States +20 more
Started: Aug 1, 2001
Safety and Efficacy of Olanzapine in the Long-term Treatment for Bipolar I Disorder, Depressed
NCT00618748COMPLETEDPHASE3
101 participants
INTERVENTIONAL
Aichi, Japan +9 more
Started: Feb 1, 2008
Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder
NCT00050206COMPLETEDPHASE4
130 participants
INTERVENTIONAL
Indianapolis, United States
Started: Nov 1, 2002
Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder
NCT00129220COMPLETEDPHASE3
224 participants
INTERVENTIONAL
Aichi, Japan +15 more
Started: Jul 1, 2005
Olanzapine Treatment of Patients With Bipolar I Disorder
NCT00510146COMPLETEDPHASE3
514 participants
INTERVENTIONAL
Beijing, China +15 more
Started: Aug 1, 2007
Olanzapine Treated Adolescents With Schizophrenia or Bipolar I Disorder
NCT00113594COMPLETEDPHASE3
100 participants
INTERVENTIONAL
Cerritos, United States +16 more
Started: Jun 1, 2005
Olanzapine Plus Carbamazepine in the Treatment of Bipolar I Mania
NCT00190892COMPLETEDPHASE4
120 participants
INTERVENTIONAL
Everton Park, Australia +12 more
Started: Sep 1, 2004
An Observational Study of Olanzapine Coated and Orodispersible Tablets Effectiveness in Schizophrenic and Bipolar Outpatients.
NCT00510211COMPLETED
1.13K participants
OBSERVATIONAL
Paris, France +2 more
Started: Apr 1, 2007
9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED)
NCT00143182COMPLETEDPHASE3
504 participants
INTERVENTIONAL
Started: Jan 7, 2005
3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)
NCT00159796COMPLETEDPHASE3
489 participants
INTERVENTIONAL
Started: Dec 14, 2004
Showing 20 of 86 total trials