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Quetiapine
Treatment for Bipolar Disorder
Typical Dosage: 50-800mg daily
Effectiveness
88%
Safety Score
40%
Clinical Trials
120
Participants
40K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe
Treatment Details
Dosage Range
50-800mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$600
Monitoring:$1,000
Side Effect Mgmt:$400
Total Annual:$2,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
0.6
Outcome-Based Costs
Cost per Responder
$3,076.9
Cost per Remission
$5,000
Comparison vs Olanzapine
Cost Difference
$-100/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Quetiapine Outcomes
for Bipolar Disorder
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+65%
Remission Rate
+40%
Common Side Effects
Sedation/Somnolence
+60%
Weight gain
+35%
Dry mouth
+20%
Dizziness
+15%
Metabolic changes (cholesterol, glucose)
+15%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
15 completed trials for Quetiapine in Bipolar Disorder
Phase III/Seroquel SR Bipolar Depression Monotherapy - US
NCT00422214COMPLETEDPHASE3
400 participants
INTERVENTIONAL
Birmingham, United States +53 more
Started: Dec 1, 2006
Pharmacokinetics of Quetiapine Across Pregnancy and Postpartum
NCT02978534COMPLETED
4 participants
OBSERVATIONAL
Chicago, United States
Started: Mar 1, 2016
Phase 3 /Seroquel SR Acute Mania Monotherapy - US
NCT00422123COMPLETEDPHASE3
447 participants
INTERVENTIONAL
Phoenix, United States +50 more
Started: Jan 1, 2007
Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders
NCT00252226COMPLETEDPHASE3
100 participants
INTERVENTIONAL
Ottawa, Canada
Started: Jun 1, 2004
Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder
NCT01195363COMPLETEDPHASE4
28 participants
INTERVENTIONAL
San Antonio, United States
Started: Apr 1, 2007
Effect of Quetiapine on Sleep Architecture in Bipolar Depression and Major Depressive Disorder
NCT00616889COMPLETED
15 participants
OBSERVATIONAL
Kingston, Canada
Started: May 1, 2006
Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder
NCT00181883COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Started: Feb 1, 2005
Quetiapine Fumarate Bipolar Maintenance Monotherapy
NCT00314184COMPLETEDPHASE3
1.25K participants
INTERVENTIONAL
Cerritos, United States +94 more
Started: Mar 1, 2005
Effects of Quetiapine on Ultrastructural Hippocampal and Neurochemical Changes in Patients With Bipolar Disorder: Searching for Antidepressant and Mood Stabilising Neurophysiology
NCT01552837COMPLETEDNA
33 participants
INTERVENTIONAL
Aachen, Germany
Started: Dec 1, 2007
Efficacy of Quetiapine XR Versus Placebo as Concomitant Treatment to Mood Stabilizers in the Control of Subsyndromal Symptoms of Bipolar Disorder
NCT01197846COMPLETEDPHASE3
28 participants
INTERVENTIONAL
Barcelona, Spain +9 more
Started: Sep 1, 2010
Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Children & Adolescents With Bipolar I Mania
NCT00090311COMPLETEDPHASE3
220 participants
INTERVENTIONAL
Scottsdale, United States +31 more
Started: Jul 1, 2004
Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression
NCT00083954COMPLETEDPHASE3
530 participants
INTERVENTIONAL
Birmingham, United States +35 more
Started: Jun 1, 2004
Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
NCT00277667COMPLETEDPHASE3
40 participants
INTERVENTIONAL
Cincinnati, United States
Started: Feb 1, 2004
A Survey on Quetiapine Extended-release Tablets in Patients With Depression in Bipolar Disorder
NCT03403790COMPLETED
369 participants
OBSERVATIONAL
Aichi, Japan +46 more
Started: Jan 15, 2018
Comparative Effectiveness Study for Bipolar Disorder
NCT01331304COMPLETEDPHASE4
482 participants
INTERVENTIONAL
Birmingham, United States +10 more
Started: Sep 1, 2010
Showing 20 of 121 total trials