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Valproate (Divalproex)
Treatment for Bipolar Disorder
Typical Dosage: 750-2500mg daily
Effectiveness
82%
Safety Score
35%
Clinical Trials
120
Participants
40K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe
Treatment Details
Dosage Range
750-2500mg daily
Time to Effect
1-3 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$300
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$45,000/QALY
QALYs Gained
0.7
Outcome-Based Costs
Cost per Responder
$2,461.5
Cost per Remission
$4,000
Comparison vs Lithium
Cost Difference
+$200/year
More expensive
QALY Difference
-0.05 QALYs
Worse outcomes
Dominance
No dominance
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
16 completed trials for Valproate (Divalproex) in Bipolar Disorder
Gulf Evaluation of VAlproate (Depakine Chrono) in maNia Study
NCT00477373COMPLETEDPHASE4
70 participants
INTERVENTIONAL
Bahrain, Bahrain +3 more
Started: Dec 1, 2006
Drug Treatment for Alcoholics With Bipolar Disorder
NCT00000439COMPLETEDPHASE2
72 participants
INTERVENTIONAL
Pittsburgh, United States
Started: Oct 1, 2000
Depakote ER in Bipolar Depression
NCT00186186COMPLETEDPHASE4
28 participants
INTERVENTIONAL
Stanford, United States
Started: Jan 1, 2004
VALID : VAlproate Versus LIthium in Bipolar Disorders
NCT00264173COMPLETEDPHASE4
270 participants
INTERVENTIONAL
Started: Feb 1, 2004
Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar
NCT00176202COMPLETEDPHASE3
65 participants
INTERVENTIONAL
Chicago, United States +2 more
Started: Apr 1, 2003
Depakote-ER for Depressive and Bipolar Depression
NCT00226343COMPLETEDPHASE4
25 participants
INTERVENTIONAL
Started: Aug 1, 2003
Lithium Versus Divalproex for Treating Pediatric Bipolar Disorder
NCT00221429COMPLETEDPHASE3
153 participants
INTERVENTIONAL
Cincinnati, United States
Started: Mar 1, 2001
Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
NCT00194116COMPLETEDPHASE3
54 participants
INTERVENTIONAL
Cleveland, United States
Started: Sep 1, 2004
An Inpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder
NCT00060905COMPLETEDPHASE3
370 participants
INTERVENTIONAL
Cerritos, United States +17 more
Started: Jan 1, 2003
Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes
NCT00397020COMPLETEDPHASE4
30 participants
INTERVENTIONAL
San Diego, United States
Started: Dec 1, 2006
Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
NCT00194129COMPLETEDPHASE3
31 participants
INTERVENTIONAL
Cleveland, United States
Started: Nov 1, 1997
Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder
NCT00199966COMPLETEDPHASE4
30 participants
INTERVENTIONAL
Milwaukee, United States
Started: Dec 1, 2003
A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescents
NCT00195780COMPLETEDPHASE3
227 participants
INTERVENTIONAL
San Diego, United States +28 more
Started: Feb 1, 2005
Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling
NCT00221975COMPLETEDPHASE3
98 participants
INTERVENTIONAL
Cleveland, United States
Started: Jul 1, 2002
Evaluate the Safety of Depakote Extended Release Tablets in the Treatment of Mania Associated With Bipolar Disorder in Children and Adolescents
NCT00195767COMPLETEDPHASE3
150 participants
INTERVENTIONAL
North Chicago, United States
Started: Jul 1, 2004
Decision-Making in Bipolar Disorder
NCT01463111COMPLETEDNA
37 participants
INTERVENTIONAL
Atlanta, United States
Started: May 1, 2011
Showing 20 of 120 total trials