Booting Earth Optimization System
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Condition
Clinical trials and treatment information for Chronic kidney disease due to diabetes mellitus type 2
Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.
Comparative Safety Scale(Higher is safer)
Time to Effect
3-6 months for sustained renal benefits
Duration
lifetime
Response Rate
80%
Remission Rate
%
Number Needed to Treat (NNT)
20
Number Needed to Harm (NNH)
20
Common Side Effects:
Annual Cost of Care
Drug Cost
$7,200
Monitoring
$1,200
Side Effects
$150
Total Annual
$8,550
Cost-Effectiveness
EXCELLENTQALYs Gained
1
ICER
$45,000/QALY
Cost per Responder
$10,687.5
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
1-2 months for albuminuria reduction, 6-12 months for sustained eGFR benefit
Duration
lifetime
Response Rate
85%
Remission Rate
%
Number Needed to Treat (NNT)
15
Number Needed to Harm (NNH)
20
Common Side Effects:
Annual Cost of Care
Drug Cost
$180
Monitoring
$1,200
Side Effects
$75
Total Annual
$1,455
Cost-Effectiveness
EXCELLENTQALYs Gained
1.5
ICER
$20,000/QALY
Cost per Responder
$1,711.76
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
6-12 months for sustained renal benefits
Duration
lifetime
Response Rate
75%
Remission Rate
%
Number Needed to Treat (NNT)
35
Number Needed to Harm (NNH)
15
Common Side Effects:
Annual Cost of Care
Drug Cost
$7,200
Monitoring
$1,700
Side Effects
$300
Total Annual
$9,200
Cost-Effectiveness
MODERATEQALYs Gained
0.5
ICER
$130,000/QALY
Cost per Responder
$12,266.67
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
6-12 months for sustained renal/CV benefits
Duration
lifetime
Response Rate
70%
Remission Rate
%
Number Needed to Treat (NNT)
45
Number Needed to Harm (NNH)
10
Common Side Effects:
Annual Cost of Care
Drug Cost
$11,500
Monitoring
$1,200
Side Effects
$200
Total Annual
$12,900
Cost-Effectiveness
MODERATEQALYs Gained
0.6
ICER
$140,000/QALY
Cost per Responder
$18,428.57
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
1-2 weeks for glycemic control, years for long-term complications
Duration
lifetime (if eGFR allows)
Response Rate
90%
Remission Rate
%
Number Needed to Treat (NNT)
25
Number Needed to Harm (NNH)
5
Common Side Effects:
Annual Cost of Care
Drug Cost
$120
Monitoring
$1,200
Side Effects
$50
Total Annual
$1,370
Cost-Effectiveness
EXCELLENTQALYs Gained
1.8
ICER
$10,000/QALY
Cost per Responder
$1,522.22
Clinical Trial Phases: