Booting Earth Optimization System
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Condition
Clinical trials and treatment information for Chronic kidney disease due to glomerulonephritis
Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.
Comparative Safety Scale(Higher is safer)
Time to Effect
1-3 months for kidney protection
Duration
lifetime
Response Rate
75%
Remission Rate
%
Number Needed to Treat (NNT)
12
Number Needed to Harm (NNH)
250
Common Side Effects:
Annual Cost of Care
Drug Cost
$20
Monitoring
$200
Side Effects
$50
Total Annual
$270
Cost-Effectiveness
EXCELLENTQALYs Gained
1
ICER
$15,000/QALY
Cost per Responder
$360
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
2-3 months for kidney/CV benefits
Duration
lifetime
Response Rate
85%
Remission Rate
%
Number Needed to Treat (NNT)
22
Number Needed to Harm (NNH)
75
Common Side Effects:
Annual Cost of Care
Drug Cost
$5,000
Monitoring
$200
Side Effects
$100
Total Annual
$5,300
Cost-Effectiveness
EXCELLENTQALYs Gained
1.4
ICER
$25,000/QALY
Cost per Responder
$6,235
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
2-6 weeks
Duration
3-6 months (induction)
Response Rate
80%
Remission Rate
60%
Number Needed to Treat (NNT)
3
Number Needed to Harm (NNH)
8
Common Side Effects:
Annual Cost of Care
Drug Cost
$1,500
Monitoring
$2,000
Side Effects
$3,000
Total Annual
$6,500
Cost-Effectiveness
EXCELLENTQALYs Gained
2.2
ICER
$30,000/QALY
Cost per Remission
$10,833
Cost per Responder
$8,125
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
1-3 months
Duration
1-3 years or more
Response Rate
68%
Remission Rate
40%
Number Needed to Treat (NNT)
5
Number Needed to Harm (NNH)
15
Common Side Effects:
Annual Cost of Care
Drug Cost
$3,000
Monitoring
$800
Side Effects
$700
Total Annual
$4,500
Cost-Effectiveness
GOODQALYs Gained
1.4
ICER
$80,000/QALY
Cost per Remission
$11,250
Cost per Responder
$6,618
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
1-3 months
Duration
Induction, then maintenance every 6-12 months
Response Rate
78%
Remission Rate
60%
Number Needed to Treat (NNT)
4
Number Needed to Harm (NNH)
35
Common Side Effects:
Annual Cost of Care
Drug Cost
$15,000
Monitoring
$800
Side Effects
$500
Total Annual
$16,300
Cost-Effectiveness
MODERATEQALYs Gained
1.7
ICER
$120,000/QALY
Cost per Remission
$27,167
Cost per Responder
$20,897
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
days-weeks for anti-inflammatory effects
Duration
3-6 months (induction), then taper
Response Rate
70%
Remission Rate
50%
Number Needed to Treat (NNT)
4
Number Needed to Harm (NNH)
8
Common Side Effects:
Annual Cost of Care
Drug Cost
$50
Monitoring
$500
Side Effects
$1,000
Total Annual
$1,550
Cost-Effectiveness
GOODQALYs Gained
1.2
ICER
$60,000/QALY
Cost per Remission
$3,100
Cost per Responder
$2,214
Clinical Trial Phases: