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FOLFOX (Fluorouracil, Leucovorin, Oxaliplatin)
Treatment for Colon and rectum cancer
Typical Dosage: Oxaliplatin 85mg/m2, Leucovorin 400mg/m2, Fluorouracil 400mg/m2 bolus then 2400mg/m2 infusion, every 2 weeks
Effectiveness
85%
Safety Score
25%
Clinical Trials
56
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
Oxaliplatin 85mg/m2, Leucovorin 400mg/m2, Fluorouracil 400mg/m2 bolus then 2400mg/m2 infusion, every 2 weeks
Time to Effect
6-9 weeks
Treatment Duration
6 months (adjuvant) or until progression (metastatic)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20,000
Monitoring:$15,000
Side Effect Mgmt:$10,000
Total Annual:$45,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$60,000/QALY
QALYs Gained
1.2
Outcome-Based Costs
Cost per Responder
$100,000
Cost per Remission
$900,000
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for FOLFOX (Fluorouracil, Leucovorin, Oxaliplatin) in Colon and rectum cancer
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
NCT07283939RECRUITINGNA
420 participants
INTERVENTIONAL
Phoenix, United States +315 more
Started: Feb 13, 2026
FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer
NCT05627635ACTIVE NOT RECRUITINGPHASE1, PHASE2
20 participants
INTERVENTIONAL
Duarte, United States
Started: May 3, 2023
Completed Clinical Trials
13 completed trials for FOLFOX (Fluorouracil, Leucovorin, Oxaliplatin) in Colon and rectum cancer
Phase 2 Study of DKN-01 in Colorectal Cancer
NCT05480306COMPLETEDPHASE2
188 participants
INTERVENTIONAL
Tucson, United States +39 more
Started: Aug 30, 2022
TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors
NCT02574663COMPLETEDPHASE1
66 participants
INTERVENTIONAL
Nashville, United States
Started: Sep 11, 2015
Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
NCT00265850COMPLETEDPHASE3
2.33K participants
INTERVENTIONAL
Mobile, United States +682 more
Started: Nov 1, 2005
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer
NCT01206530COMPLETEDPHASE1, PHASE2
50 participants
INTERVENTIONAL
Philadelphia, United States
Started: Sep 1, 2010
Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer
NCT00098787COMPLETEDPHASE2
247 participants
INTERVENTIONAL
Greenbrae, United States +109 more
Started: Sep 8, 2005
Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases
NCT00268398COMPLETEDPHASE3
284 participants
INTERVENTIONAL
Avignon, France +31 more
Started: Jul 1, 2002
PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study
NCT00911170COMPLETEDPHASE3
847 participants
INTERVENTIONAL
Muscle Shoals, United States +153 more
Started: Nov 3, 2009
A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer
NCT00060411COMPLETEDPHASE1
24 participants
INTERVENTIONAL
Baltimore, United States
Started: Jun 1, 2003
MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer
NCT02041481COMPLETEDPHASE1
26 participants
INTERVENTIONAL
Duarte, United States
Started: Jun 1, 2014
Neo-adjuvant Chemoradiation With Oxaliplatin/5-FU in Rectal Cancer
NCT00831181COMPLETEDPHASE2
27 participants
INTERVENTIONAL
New York, United States +1 more
Started: Jul 1, 2004
Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer
NCT00004102COMPLETEDPHASE2
INTERVENTIONAL
New York, United States
Started: Jan 1, 1999
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Previously Treated With Irinotecan
NCT00016978COMPLETEDPHASE2
40 participants
INTERVENTIONAL
Scottsdale, United States +23 more
Started: Apr 1, 2001
Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
NCT00016198COMPLETEDPHASE2
INTERVENTIONAL
Tucson, United States +73 more
Started: May 1, 2001
Showing 20 of 58 total trials