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Metformin
Treatment for Diabetes mellitus type 2
Typical Dosage: 500-2550 mg daily
Effectiveness
88%
Safety Score
65%
Clinical Trials
1,523
Participants
2M
Comparative Safety Scale(Higher is safer)
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Meth💀
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65
DangerousModerateSafe
Treatment Details
Dosage Range
500-2550 mg daily
Time to Effect
1-2 weeks
Treatment Duration
Lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10000(Treat 10000 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$40
Monitoring:$425
Side Effect Mgmt:$50
Total Annual:$515
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.75
Outcome-Based Costs
Cost per Responder
$686.67
Cost per Remission
$7,357.14
Metformin Outcomes
for Diabetes mellitus type 2
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Remission Rate
+7%
Common Side Effects
Diarrhea
+35%
Nausea/Vomiting
+15%
Abdominal discomfort
+18%
Lactic acidosis
+0.1%
B12 deficiency
+7%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
13 completed trials for Metformin in Diabetes mellitus type 2
A Clinical Study to Compare the Pharmacokinetic Characteristics of CKD-395 0.5/1000 mg in Healthy Male Volunteers
NCT02565368COMPLETEDPHASE1
26 participants
INTERVENTIONAL
Jeonju, South Korea
Started: Jul 1, 2015
A Clinical Study to Compare the Pharmacokinetic Characteristics of CKD-395 0.25/500mg in Healthy Male Volunteers
NCT02685774COMPLETEDPHASE1
26 participants
INTERVENTIONAL
Jeonju, South Korea
Started: Feb 1, 2016
Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM
NCT00577590COMPLETEDNA
78 participants
INTERVENTIONAL
St Louis, United States
Started: Oct 1, 2003
A Study of DBPR108 and Metformin Hydrochloride Combination Therapy in Patients With T2DM
NCT04218734COMPLETEDPHASE3
214 participants
INTERVENTIONAL
Beijing, China
Started: Jan 14, 2020
Effects of Empagliflozin-Metformin, Sitagliptin-Metformin, and Metformin on Adipokines in Type 2 Diabetes
NCT07531108COMPLETEDPHASE4
186 participants
INTERVENTIONAL
Erbil, Iraq
Started: Nov 15, 2024
Dose-finding of PB-119 Administered Subcutaneously Once Weekly Versus Placebo in Subjects With Type 2 Diabetes
NCT03604419COMPLETEDPHASE2
214 participants
INTERVENTIONAL
Miami, United States
Started: Jun 13, 2018
Efficacy of Pioglitazone in Participants With Inadequately Controlled Type 2 Diabetes Mellitus Treated With Stable Triple Oral Therapy
NCT01972724COMPLETEDPHASE4
114 participants
INTERVENTIONAL
Chagwon, South Korea +8 more
Started: Dec 16, 2013
Bioequivalence Study for Acarbose / Metformin FDC
NCT01728740COMPLETEDPHASE1
40 participants
INTERVENTIONAL
Seoul, South Korea
Started: Sep 1, 2012
A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Asian Diabetes Patients
NCT01505426COMPLETEDPHASE3
171 participants
INTERVENTIONAL
Busan, South Korea +11 more
Started: Nov 28, 2011
A Clinical Study to Compare the Pharmacokinetic Characteristics of CKD-395 0.25/750 mg in Healthy Male Volunteers
NCT02627027COMPLETEDPHASE1
26 participants
INTERVENTIONAL
Jeonju, South Korea
Started: Aug 1, 2015
Bioequivalence Study of 500 mg and 1000 mg Glucophage (Metformin) Tablets in Healthy Subjects
NCT01068730COMPLETEDPHASE1
28 participants
INTERVENTIONAL
Austin, United States
Started: Feb 1, 2010
Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients
NCT02151461COMPLETEDPHASE2
96 participants
INTERVENTIONAL
Chino, United States +8 more
Started: Jul 1, 2014
An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic Patients
NCT02435277COMPLETEDPHASE2
50 participants
INTERVENTIONAL
Chino, United States +8 more
Started: Oct 1, 2014
Showing 20 of 1559 total trials