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Varenicline solution (nasal spray)
Treatment for Dry Eye Disease
Typical Dosage: One spray in each nostril twice daily
Effectiveness
78%
Safety Score
75%
Clinical Trials
4
Participants
1.8K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
One spray in each nostril twice daily
Time to Effect
Within days to 2 weeks
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$9,000
Monitoring:$600
Side Effect Mgmt:$50
Total Annual:$9,650
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$11,000/QALY
QALYs Gained
0.06
Outcome-Based Costs
Cost per Responder
$17,545
Cost per Remission
$64,333
Comparison vs Artificial Tears
Cost Difference
+$9,050/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$6,570
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$90/year
Travel + wait time
Insurance Admin Cost
$80/year
Prior auth, claims
Rx Price
$9,000/year
Potential OTC Price
$800/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWVarenicline solution (nasal spray) Outcomes
for Dry Eye Disease
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+55%
Remission Rate
+15%
Common Side Effects
Sneezing
+82%
Cough
+16%
Throat irritation
+13%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
4 completed trials for Varenicline solution (nasal spray) in Dry Eye Disease
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of OC-01 in Adult Chinese With Dry Eye Disease
NCT05576415COMPLETEDPHASE1
9 participants
INTERVENTIONAL
Shanghai, China
Started: Dec 7, 2022
Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease
NCT05378945COMPLETEDPHASE3
340 participants
INTERVENTIONAL
Hefei, China +19 more
Started: Jul 22, 2022
Nasal Spray Study in Sjogren's Dry Eye Disease
NCT05700422COMPLETEDPHASE4
39 participants
INTERVENTIONAL
Philadelphia, United States
Started: May 1, 2023
Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
NCT05514041COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Venice, United States
Started: Oct 11, 2022