Booting Earth Optimization System
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Condition
Clinical trials and treatment information for HIV/AIDS - Extensively drug-resistant Tuberculosis
Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.
Comparative Safety Scale(Higher is safer)
Time to Effect
2-4 weeks (sputum conversion), 1-2 months (clinical improvement)
Duration
6-9 months
Response Rate
89%
Remission Rate
89%
Number Needed to Treat (NNT)
2
Number Needed to Harm (NNH)
7
Common Side Effects:
Annual Cost of Care
Drug Cost
$41,000
Monitoring
$4,000
Side Effects
$6,000
Total Annual
$51,000
Cost-Effectiveness
EXCELLENTQALYs Gained
8
ICER
$6,375/QALY
Cost per Remission
$57,303
Cost per Responder
$57,303
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
2-4 weeks (sputum conversion), 1-2 months (clinical improvement)
Duration
6-9 months
Response Rate
88%
Remission Rate
88%
Number Needed to Treat (NNT)
2
Number Needed to Harm (NNH)
7
Common Side Effects:
Annual Cost of Care
Drug Cost
$40,000
Monitoring
$4,000
Side Effects
$5,000
Total Annual
$49,000
Cost-Effectiveness
EXCELLENTQALYs Gained
8
ICER
$6,125/QALY
Cost per Remission
$55,682
Cost per Responder
$55,682
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
Contributes to sputum conversion within weeks (as part of regimen)
Duration
Typically 6-9 months (as part of regimen)
Response Rate
%
Remission Rate
%
Number Needed to Harm (NNH)
7
Common Side Effects:
Annual Cost of Care
Drug Cost
$3,000
Monitoring
$2,000
Side Effects
$3,000
Total Annual
$8,000
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
2-3 months (sputum conversion), 3-6 months (clinical improvement)
Duration
18-24 months
Response Rate
75%
Remission Rate
75%
Number Needed to Treat (NNT)
4
Number Needed to Harm (NNH)
8
Common Side Effects:
Annual Cost of Care
Drug Cost
$53,000
Monitoring
$7,000
Side Effects
$8,000
Total Annual
$68,000
Cost-Effectiveness
EXCELLENTQALYs Gained
6
ICER
$11,333/QALY
Cost per Remission
$90,667
Cost per Responder
$90,667
Clinical Trial Phases:
Comparative Safety Scale(Higher is safer)
Time to Effect
Contributes to regimen effect over months
Duration
Typically 18-24 months (as part of regimen)
Response Rate
%
Remission Rate
%
Number Needed to Harm (NNH)
15
Common Side Effects:
Annual Cost of Care
Drug Cost
$800
Monitoring
$500
Side Effects
$1,000
Total Annual
$2,300
Clinical Trial Phases: