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Bedaquiline (as part of a longer oral regimen)
Treatment for HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance
Typical Dosage: 400mg daily for 2 weeks, then 200mg three times a week for 22 weeks
Effectiveness
80%
Safety Score
65%
Clinical Trials
30
Participants
5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
400mg daily for 2 weeks, then 200mg three times a week for 22 weeks
Time to Effect
2-3 months for significant clinical improvement
Treatment Duration
Bedaquiline component 6-9 months, total regimen 9-18 months
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
25(Treat 25 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$45,000
Monitoring:$4,000
Side Effect Mgmt:$3,000
Total Annual:$52,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$50,000/QALY
QALYs Gained
10
Outcome-Based Costs
Cost per Responder
$65,000
Cost per Remission
$65,000
Comparison vs Older, longer MDR-TB regimens without Bedaquiline
Cost Difference
+$2,000/year
More expensive
QALY Difference
+1.00 QALYs
Better outcomes
Dominance
No dominance
Bedaquiline (as part of a longer oral regimen) Outcomes
for HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov