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BPaL Regimen (Bedaquiline, Pretomanid, Linezolid)
Treatment for HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance
Typical Dosage: Bedaquiline: 400mg daily for 2 weeks, then 200mg 3x/week for 22 weeks; Pretomanid: 200mg daily for 26 weeks; Linezolid: 300-600mg daily for 26 weeks
Effectiveness
90%
Safety Score
58%
Clinical Trials
15
Participants
1.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
Bedaquiline: 400mg daily for 2 weeks, then 200mg 3x/week for 22 weeks; Pretomanid: 200mg daily for 26 weeks; Linezolid: 300-600mg daily for 26 weeks
Time to Effect
1-2 months for significant clinical improvement
Treatment Duration
6 months
Evidence Quality
HIGHNumber Needed to Treat (NNT)
2.5(Treat 2.5 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
7(Treat 7 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$40,000
Monitoring:$3,500
Side Effect Mgmt:$3,000
Total Annual:$46,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$45,000/QALY
QALYs Gained
12
Outcome-Based Costs
Cost per Responder
$51,667
Cost per Remission
$51,667
Comparison vs Longer-course individualized MDR-TB regimens
Cost Difference
$-15,000/year
Less expensive
QALY Difference
+0.80 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
BPaL Regimen (Bedaquiline, Pretomanid, Linezolid) Outcomes
for HIV/AIDS - Multidrug-resistant Tuberculosis without extensive drug resistance
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Peripheral neuropathy
+60%
Myelosuppression (anemia, thrombocytopenia)
+15%
QT prolongation
+8%
Optic neuropathy
+6%
Nausea/vomiting
+18%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov