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Cryotherapy (Liquid Nitrogen)
Treatment for HPV Infection
Typical Dosage: Applied for 5-30 seconds, repeated weekly/bi-weekly
Effectiveness
70%
Safety Score
80%
Clinical Trials
11
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe
Treatment Details
Dosage Range
Applied for 5-30 seconds, repeated weekly/bi-weekly
Time to Effect
1-4 weeks per session
Treatment Duration
Multiple sessions over 4-12 weeks
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$1,000
Side Effect Mgmt:$50
Total Annual:$1,050
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
Outcome-Based Costs
Cost per Responder
$1,500
Cost per Remission
$1,500
Comparison vs Imiquimod
Cost Difference
$-200/year
Less expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Cryotherapy (Liquid Nitrogen) Outcomes
for HPV Infection
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Remission Rate
+70%
Common Side Effects
Pain
+85%
Blistering
+60%
Ulceration
+30%
Hypopigmentation
+20%
Scarring
+7%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for Cryotherapy (Liquid Nitrogen) in HPV Infection
Comparison of Efficacy of Topical Adaplene Gel Versus Crythotherapy in Recurrent Plantar Warts
NCT07016360RECRUITINGPHASE4
98 participants
INTERVENTIONAL
Peshawar, Pakistan
Started: Sep 15, 2025
Completed Clinical Trials
6 completed trials for Cryotherapy (Liquid Nitrogen) in HPV Infection
Cost-effectiveness of EndWarts® FREEZE - an Alternative Home Cryotherapy Device for Wart Treatment
NCT04781244COMPLETEDNA
22 participants
INTERVENTIONAL
Bangkok Noi, Thailand
Started: Nov 12, 2020
A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
NCT01084824COMPLETEDNA
70 participants
INTERVENTIONAL
Coeur d'Alene, United States
Started: Jun 1, 2007
Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts
NCT05712811COMPLETEDNA
60 participants
INTERVENTIONAL
Abbottābād, Pakistan
Started: Jun 1, 2022
Serum Galectin-3 as a Marker of Human Papillomavirus Infection
NCT06005389COMPLETED
100 participants
OBSERVATIONAL
Asyut, Egypt
Started: Dec 1, 2021
Cold Atmospheric Plasma Device for Pediatric Molluscum and Verruca
NCT05070754COMPLETEDPHASE4
17 participants
INTERVENTIONAL
Charleston, United States
Started: Dec 2, 2021
Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts
NCT03183765COMPLETEDPHASE4
48 participants
INTERVENTIONAL
Asyut, Egypt
Started: Aug 1, 2017