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Zolpidem
Treatment for Insomnia
Typical Dosage: 5-10 mg at bedtime
Effectiveness
70%
Safety Score
45%
Clinical Trials
80
Participants
35K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
5-10 mg at bedtime
Time to Effect
immediate
Treatment Duration
short-term (2-4 weeks)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
20(Treat 20 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATEICER
$90,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$385
Cost per Remission
$1,667
Zolpidem Outcomes
for Insomnia
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+65%
Remission Rate
+15%
Common Side Effects
Drowsiness
+20%
Dizziness
+10%
Headache
+8%
Nausea
+6%
Amnesia
+3%
Complex sleep behaviors
+1%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for Zolpidem in Insomnia
Efficacy and Safety of APSTZD in the Treatment of Insomnia Disorder
NCT07420816NOT YET RECRUITINGPHASE2
222 participants
INTERVENTIONAL
Bragança Paulista, Brazil
Started: Mar 26, 2026
Safety and Efficacy Study of YZJ-1139 Tablets in Insomnia Disorder
NCT06975514RECRUITINGPHASE3
60 participants
INTERVENTIONAL
Beijing, China +15 more
Started: Mar 25, 2025
Completed Clinical Trials
16 completed trials for Zolpidem in Insomnia
Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia
NCT01896336COMPLETEDPHASE4
67 participants
INTERVENTIONAL
São Paulo, Brazil
Started: Feb 18, 2013
Study to Validate the Questionnaire Called IDSIQ™ in Patients With Insomnia Disorder
NCT03056053COMPLETEDPHASE2
113 participants
INTERVENTIONAL
Santa Monica, United States +8 more
Started: Feb 15, 2017
Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia
NCT03774810COMPLETEDPHASE4
197 participants
INTERVENTIONAL
Philadelphia, United States
Started: Apr 15, 2019
A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users
NCT03158025COMPLETEDPHASE1
39 participants
INTERVENTIONAL
Toronto, Canada
Started: Apr 19, 2017
A Study of Zolpidem Tartrate Sublingual Tablet in Adult Patients With Insomnia
NCT00380081COMPLETEDPHASE3
82 participants
INTERVENTIONAL
Started: Apr 1, 2006
Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)
NCT02783729COMPLETEDPHASE3
1.01K participants
INTERVENTIONAL
Jasper, United States +101 more
Started: May 31, 2016
Bioequivalency Study of Zolpidem Tartrate Under Fed Conditions
NCT00602719COMPLETEDNA
30 participants
INTERVENTIONAL
Fargo, United States
Started: Mar 1, 2004
Bioequivalency Study of Zolpidem Tartrate Under Fasting Conditions
NCT00601666COMPLETEDNA
30 participants
INTERVENTIONAL
Fargo, United States
Started: Mar 1, 2004
Stilnox Treatment in Elderly Patients With Insomnia
NCT00359229COMPLETEDPHASE4
115 participants
INTERVENTIONAL
Started: Jul 1, 2006
Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
NCT01485393COMPLETEDNA
10 participants
INTERVENTIONAL
Boston, United States
Started: Jan 1, 2015
Ambien CR For Treatment Of Insomnia Associated With Depression When Used Concomitantly With Lexapro
NCT00296179COMPLETEDPHASE4
372 participants
INTERVENTIONAL
Started: Feb 1, 2006
Long Term Treatment With Zolpidem: Nightly and Intermittent Dosing
NCT00156533COMPLETEDPHASE4
20 participants
INTERVENTIONAL
Rochester, United States
Started: Mar 1, 2005
A Study of Zolpidem Tartrate Sublingual Tablet in Adult Patients With Insomnia
NCT00466193COMPLETEDPHASE3
295 participants
INTERVENTIONAL
Durham, United States
Started: May 1, 2007
Residual Effects of Zolpidem Tartrate Extended Release and Eszopiclone Vs Placebo
NCT00283790COMPLETEDPHASE4
36 participants
INTERVENTIONAL
Bridgewater, United States
Started: Jan 1, 2006
Zolpidem or Exercise for Insomnia?
NCT03160404COMPLETEDEARLY_PHASE1
34 participants
INTERVENTIONAL
Jatai, Brazil
Started: Apr 16, 2018
Safety and Efficacy of Chronic Hypnotic Use
NCT01006525COMPLETED
116 participants
OBSERVATIONAL
Detroit, United States
Started: Dec 1, 2005
Showing 20 of 83 total trials