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Memantine
Treatment for Lewy Body Dementia
Typical Dosage: 5-20 mg daily, titrated
Effectiveness
55%
Safety Score
70%
Clinical Trials
4
Participants
1.6K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
5-20 mg daily, titrated
Time to Effect
2-4 weeks
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
70%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$750
Side Effect Mgmt:$75
Total Annual:$900
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$12,857/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$3,600
Prescription Access Economics
Annual Societal Loss per Patient
$655
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$240/year
Prior auth, claims
Rx Price
$75/year
Potential OTC Price
$30/year
Estimated if OTC available
Early Treatment Benefit
+0.02 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
LOWWARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
4 completed trials for Memantine in Lewy Body Dementia
Memantine Versus Placebo in Parkinson's Disease Dementia or Dementia With Lewy Bodies
NCT00855686COMPLETEDPHASE4
199 participants
INTERVENTIONAL
Munich, Germany
Started: Jan 1, 2007
Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)
NCT00630500COMPLETEDPHASE2
75 participants
INTERVENTIONAL
Stavanger, Norway +3 more
Started: Feb 1, 2006
Monitoring Anti-Dementia Drugs by Serum Levels
NCT04117178COMPLETEDPHASE4
132 participants
INTERVENTIONAL
Roskilde, Denmark
Started: Feb 4, 2020
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
NCT02860338COMPLETED
900 participants
OBSERVATIONAL
Started: Jan 1, 2009