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Atovaquone-Proguanil
Treatment for Malaria
Typical Dosage: Adults: 4 tablets (250mg atovaquone/100mg proguanil) once daily for 3 days
Effectiveness
95%
Safety Score
68%
Clinical Trials
36
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
Adults: 4 tablets (250mg atovaquone/100mg proguanil) once daily for 3 days
Time to Effect
24-48 hours
Treatment Duration
3 days
Evidence Quality
HIGHConfidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$50
Side Effect Mgmt:$10
Total Annual:$135
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$142.1
Cost per Remission
$142.1
Comparison vs Artemether-Lumefantrine
Cost Difference
+$65/year
More expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Atovaquone-Proguanil Outcomes
for Malaria
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Abdominal pain
+20%
Nausea/Vomiting
+15%
Diarrhea
+10%
Headache
+10%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
16 completed trials for Atovaquone-Proguanil in Malaria
Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension
NCT01858831COMPLETEDPHASE1
30 participants
INTERVENTIONAL
Kagoshima, Japan
Started: Apr 1, 2012
Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients
NCT00421473COMPLETEDPHASE4
79 participants
INTERVENTIONAL
Arnhem, Netherlands +4 more
Started: Mar 1, 2007
Weekly Dosing of Malarone ® for Prevention of Malaria
NCT00984256COMPLETEDPHASE2
35 participants
INTERVENTIONAL
Silver Spring, United States
Started: Sep 1, 2009
Atoguanil BA Study
NCT04866602COMPLETEDPHASE1
16 participants
INTERVENTIONAL
London, United Kingdom
Started: Nov 17, 2021
Azithromycin Plus Chloroquine Versus Atovaquone-Proguanil For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In South America
NCT00084227COMPLETEDPHASE2, PHASE3
244 participants
INTERVENTIONAL
Started: Jul 1, 2004
Chloroquine Alone or in Combination for Malaria in Children in Malawi
NCT00379821COMPLETEDPHASE3
640 participants
INTERVENTIONAL
Blantyre, Malawi
Started: Feb 1, 2007
Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function
NCT00444106COMPLETEDPHASE4
265 participants
INTERVENTIONAL
Tumaco, Colombia
Started: May 1, 2007
Ototoxicity of Artemether / Lumefantrine (Coartem) and Other Antimalarials
NCT00451139COMPLETEDPHASE4
INTERVENTIONAL
Jimma, Ethiopia
DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria
NCT02450578COMPLETEDPHASE1
22 participants
INTERVENTIONAL
Tübingen, Germany
Started: Oct 1, 2015
Evaluation of the Riamet® Versus Malarone® in the Treatment of Uncomplicated Malaria
NCT01150344COMPLETEDPHASE4
317 participants
INTERVENTIONAL
Bobigny, France
Started: Jul 1, 2010
Safety and Efficacy Study of IV Artesunate to Treat Malaria
NCT00298610COMPLETEDPHASE2
30 participants
INTERVENTIONAL
Kisumu, Kenya
Started: Mar 1, 2006
Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis
NCT02080026COMPLETEDNA
15 participants
INTERVENTIONAL
Nijmegen, Netherlands
Started: Jun 1, 2014
A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)
NCT06294912COMPLETEDPHASE1
16 participants
INTERVENTIONAL
South Brisbane, Australia
Started: Apr 18, 2024
Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis
NCT02858817COMPLETEDPHASE1
30 participants
INTERVENTIONAL
Started: Nov 28, 2016
Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites
NCT01660854COMPLETEDNA
21 participants
INTERVENTIONAL
Leiden, Netherlands
Started: Jul 1, 2012
Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2)
NCT05974267COMPLETEDPHASE2
192 participants
INTERVENTIONAL
Ouagadougou, Burkina Faso +3 more
Started: Nov 28, 2023
Showing 20 of 36 total trials