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Therapeutic Lifestyle Changes (Diet and Exercise)
Treatment for Metabolic Syndrome
Typical Dosage: 150-300 minutes moderate-intensity exercise weekly, balanced hypocaloric diet
Effectiveness
90%
Safety Score
95%
Clinical Trials
38
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
150-300 minutes moderate-intensity exercise weekly, balanced hypocaloric diet
Time to Effect
3-6 months for significant changes
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$-5,000/QALY
QALYs Gained
1.2
Outcome-Based Costs
Cost per Responder
$333
Cost per Remission
$500
Therapeutic Lifestyle Changes (Diet and Exercise) Outcomes
for Metabolic Syndrome
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+75%
Remission Rate
+50%
Common Side Effects
Muscle soreness (exercise)
+30%
Fatigue (initial phase)
+20%
Hunger/cravings (diet)
+40%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
4 active trials recruiting for Therapeutic Lifestyle Changes (Diet and Exercise) in Metabolic Syndrome
Evaluation of Lifestyle Modification on Cardiovascular Risk
NCT05417698ACTIVE NOT RECRUITINGNA
60 participants
INTERVENTIONAL
Swansea, United Kingdom
Started: Aug 15, 2022
Lifestyle-modifying Interventions in Low-risk MDS Patients
NCT05433805NOT YET RECRUITINGNA
36 participants
INTERVENTIONAL
Started: Apr 1, 2023
Norwegian Mental Illness Heart Health Study
NCT07085923RECRUITINGNA
70 participants
INTERVENTIONAL
Oslo, Norway
Started: Sep 16, 2025
Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes: Plant-based Diet and Physical Exercise
NCT06959043RECRUITINGNA
60 participants
INTERVENTIONAL
São Paulo, Brazil
Started: Nov 22, 2022
Completed Clinical Trials
12 completed trials for Therapeutic Lifestyle Changes (Diet and Exercise) in Metabolic Syndrome
Therapeutic Lifestyle Modifications to Reduce Burden of Chronic Disease
NCT01277614COMPLETEDNA
144 participants
INTERVENTIONAL
Saint Augustine, Trinidad and Tobago
Started: Sep 1, 2010
Changes in the Hypotalamic-pituitary Region of Patients With Metabolic Syndrome and Obesity
NCT03458533COMPLETED
69 participants
OBSERVATIONAL
Rome, Italy
Started: Nov 1, 2016
The Effect of Diet and Exercise in Heart Failure
NCT00297154COMPLETEDNA
20 participants
INTERVENTIONAL
Started: Mar 1, 2005
Long-term Benefits of Abdominal Fat Loss in Abdominally Obese Dyslipidemic Patients (SYNERGIE Study)
NCT06158191COMPLETEDNA
186 participants
INTERVENTIONAL
Started: Mar 26, 2004
A Comparison of a PULSE Diet and the TLC Diet on Reproductive, Metabolic Parameters in Women with PCOS
NCT05428566COMPLETEDNA
144 participants
INTERVENTIONAL
Amman, Jordan +1 more
Started: Jan 1, 2022
CHANGE -it is About Life
NCT01585493COMPLETEDPHASE3
428 participants
INTERVENTIONAL
Copenhagen, Denmark
Started: Dec 1, 2012
Lifestyle Intervention for Polycystic Ovary Syndrome: Pulse-Based Diet and Exercise
NCT01288638COMPLETEDNA
95 participants
INTERVENTIONAL
Saskatoon, Canada
Started: Jan 1, 2011
Exercise and Weight Loss for Improving Mobility in Older Adults Who Are Obese
NCT00119795COMPLETEDNA
288 participants
INTERVENTIONAL
Greensboro, United States +2 more
Started: Aug 1, 2005
Lifestyle Intervention Targetting Obesity and Insulin Resistance in Chronic Hepatitis C
NCT00755742COMPLETEDNA
24 participants
INTERVENTIONAL
Toronto, Canada
Started: Nov 1, 2008
Parent Supported Weight Reduction in Down Syndrome
NCT01256112COMPLETEDNA
21 participants
INTERVENTIONAL
Waltham, United States
Started: Sep 1, 2006
The Pick Two to Stick To Habit Development Intervention
NCT03370419COMPLETEDNA
40 participants
INTERVENTIONAL
Started: Jan 13, 2016
Culturally-adapted Diabetes Prevention Lifestyle Intervention for Latinos (E-LITE Latinos)
NCT02459691COMPLETEDNA
191 participants
INTERVENTIONAL
Started: Sep 1, 2014
Showing 20 of 37 total trials