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Topiramate
Treatment for Migraine
Typical Dosage: 50-100mg daily, titrated
Effectiveness
68%
Safety Score
58%
Clinical Trials
67
Participants
30K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
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Chemo☢️
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Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
50-100mg daily, titrated
Time to Effect
2-4 weeks
Treatment Duration
Long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
12(Treat 12 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$300
Side Effect Mgmt:$200
Total Annual:$700
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.08
Outcome-Based Costs
Cost per Responder
$1,556
Cost per Remission
$7,000
Topiramate Outcomes
for Migraine
Efficacy Outcomes
Overall Effectiveness
+68%
Response Rate
+45%
Remission Rate
+10%
Common Side Effects
Paresthesia
+40%
Cognitive slowing
+20%
Fatigue
+15%
Weight loss
+10%
Kidney stones
+2%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
19 completed trials for Topiramate in Migraine
Pharmacokinetics and Safety of Intravenous Topiramate in Adult Patients
NCT00753493COMPLETEDPHASE1
20 participants
INTERVENTIONAL
Minneapolis, United States
Started: Aug 1, 2008
The Prolonged Use of Topiramate for Preventing Migraine Headaches
NCT00216619COMPLETEDPHASE3
834 participants
INTERVENTIONAL
Innsbruck, Austria +67 more
Started: Nov 1, 2003
Continuous Treatment Study of Topiramate in Migraine Participants
NCT01799590COMPLETEDPHASE2
296 participants
INTERVENTIONAL
Chitose, Japan +24 more
Started: Aug 1, 2007
Topiramate and Cerebrovascular Response in Migraineurs
NCT02424318COMPLETEDPHASE4
19 participants
INTERVENTIONAL
Started: Dec 1, 2008
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
NCT00297336COMPLETED
80 participants
OBSERVATIONAL
Started: Mar 1, 2005
Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache.
NCT00212810COMPLETEDPHASE4
385 participants
INTERVENTIONAL
Started: Sep 1, 2005
The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users
NCT03335163COMPLETEDPHASE1
48 participants
INTERVENTIONAL
Aurora, United States
Started: Mar 15, 2018
The Effectiveness and Safety of Topiramate on Prevention of Chronic Migraine
NCT00216606COMPLETEDPHASE3
59 participants
INTERVENTIONAL
Started: Dec 1, 2003
Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults
NCT02191579COMPLETEDPHASE4
282 participants
INTERVENTIONAL
Phoenix, United States +31 more
Started: Aug 5, 2014
A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine
NCT00236509COMPLETEDPHASE3
763 participants
INTERVENTIONAL
Started: Feb 1, 2001
A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine
NCT00231595COMPLETEDPHASE3
768 participants
INTERVENTIONAL
Started: Mar 1, 2001
A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine
NCT01081795COMPLETEDPHASE2
387 participants
INTERVENTIONAL
Bunkyō City, Japan +28 more
Started: Apr 1, 2007
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
NCT00846495COMPLETEDPHASE4
55 participants
INTERVENTIONAL
Oviedo, United States +1 more
Started: Aug 1, 2009
A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children
NCT00237302COMPLETEDPHASE3
162 participants
INTERVENTIONAL
Started: Jul 1, 2001
An Open Label Extension of a Study of Topiramate in Chronic Migraine.
NCT00210873COMPLETEDPHASE3
200 participants
INTERVENTIONAL
Started: Feb 1, 2004
An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention.
NCT00210860COMPLETEDPHASE3
142 participants
INTERVENTIONAL
Started: Sep 1, 2004
The Evaluation of Pharmacokinetic/Pharmacodynamic Characteristics and Safety of QDX in Healthy Korean Male Subjects
NCT04401137COMPLETEDPHASE1
42 participants
INTERVENTIONAL
Seoul, South Korea
Started: Jul 1, 2020
A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
NCT00210912COMPLETEDPHASE3
328 participants
INTERVENTIONAL
Started: Sep 1, 2003
An Efficacy and Tolerability Study of Topiramate in Participants With Migraine
NCT01060111COMPLETEDPHASE4
250 participants
INTERVENTIONAL
Busan, South Korea +5 more
Started: Jul 1, 2006
Showing 20 of 68 total trials