Booting Earth Optimization System
Thank you for your patience. Your civilization is very important to us.
Zoledronic Acid
Treatment for Osteoporosis
Typical Dosage: 5 mg intravenous infusion once yearly
Effectiveness
65%
Safety Score
65%
Clinical Trials
112
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
5 mg intravenous infusion once yearly
Time to Effect
6-12 months
Treatment Duration
3-6 years
Evidence Quality
HIGHNumber Needed to Treat (NNT)
15(Treat 15 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$250
Monitoring:$250
Side Effect Mgmt:$50
Total Annual:$550
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$-3,000/QALY
QALYs Gained
0.18
Zoledronic Acid Outcomes
for Osteoporosis
Efficacy Outcomes
Overall Effectiveness
+65%
Common Side Effects
Acute phase reaction (fever, myalgia, arthralgia)
+25%
Hypocalcemia
+3%
Renal impairment
+2%
Osteonecrosis of the jaw (ONJ)
+0.05%
Atypical femoral fracture (AFF)
+0.01%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for Zoledronic Acid in Osteoporosis
Step-down Therapy After Long-term Osteoporosis Treatment
NCT07281586RECRUITINGPHASE4
44 participants
INTERVENTIONAL
Douliu, Taiwan
Started: Jan 1, 2026
The Optimised Use of Romozosumab Study
NCT06059222RECRUITINGPHASE4
270 participants
INTERVENTIONAL
Aarhus, Denmark
Started: Oct 2, 2023
Completed Clinical Trials
16 completed trials for Zoledronic Acid in Osteoporosis
Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis
NCT03087851COMPLETEDPHASE4
61 participants
INTERVENTIONAL
Aarhus, Denmark
Started: Mar 13, 2017
A Clinical Trial to Evaluate Efficacy of Once or Twice ZOledronic Acid After Different Duration of denOsumMab Administration in Postmenopausal Women With Osteoporosis (ZOOM Study)
NCT05361408COMPLETEDPHASE4
114 participants
INTERVENTIONAL
Seoul, South Korea
Started: Feb 11, 2022
Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women
NCT00361595COMPLETEDNA
35 participants
INTERVENTIONAL
Cleveland, United States
Started: Aug 1, 2006
The Optimal Sequential Therapy After Long Term Denosumab Treatment
NCT05091099COMPLETEDPHASE4
44 participants
INTERVENTIONAL
Douliu, Taiwan
Started: Jan 10, 2022
Zoledronic Acid Administration in Acute Spinal Cord Injury
NCT02042872COMPLETEDPHASE4
21 participants
INTERVENTIONAL
West Orange, United States
Started: May 1, 2006
1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
NCT01197300COMPLETEDPHASE3
25 participants
INTERVENTIONAL
Westmead, Australia +9 more
Started: Oct 25, 2010
Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)
NCT00145327COMPLETEDPHASE3
2.46K participants
INTERVENTIONAL
Tucson, United States +30 more
Started: May 1, 2005
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
NCT00520052COMPLETEDNA
58 participants
INTERVENTIONAL
Upton, Wirral, United Kingdom
Started: Aug 1, 2003
Efficacy and Safety of Zoledronic Acid in the Prevention and Treatment of Corticosteroid Induced Osteoporosis
NCT00100620COMPLETEDPHASE3
802 participants
INTERVENTIONAL
Birmingham, United States +5 more
Started: Jun 1, 2004
Feasibility of Doctors' Rooms-based Infusion of Zoledronic Acid
NCT00745485COMPLETEDPHASE4
186 participants
INTERVENTIONAL
Blacktown, Australia +13 more
Started: Aug 1, 2008
Switching Osteoporosis Patients Currently on Oral Bisphosphonate to Zoledronic Acid
NCT00097812COMPLETEDPHASE3
220 participants
INTERVENTIONAL
Santa Rosa, United States +12 more
Started: May 1, 2004
Efficacy and Safety of Zoledronic Acid for the Treatment of Osteoporosis in Men
NCT00097825COMPLETEDPHASE3
288 participants
INTERVENTIONAL
Tucson, United States +25 more
Started: Apr 1, 2004
A Study of the Clinical Safety, Tolerability, and Efficacy of Zoledronic Acid Compared to an Oral Bisphosphonate
NCT00100555COMPLETEDPHASE3
120 participants
INTERVENTIONAL
Birmingham, United States +17 more
Started: Jun 1, 2004
Effect of Zoledronic Acid on Femoral Bone Loss Following Total Hip Arthroplasty
NCT01267279COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Started: Jan 1, 2005
Denosumab Sequential Therapy
NCT03868033COMPLETEDPHASE4
101 participants
INTERVENTIONAL
Taipei, Taiwan
Started: Apr 12, 2019
Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study
NCT02632916COMPLETEDPHASE2
10 participants
INTERVENTIONAL
Ottawa, Canada
Started: Aug 1, 2016
Showing 20 of 114 total trials