Condition

Pancreatitis

Clinical trials and treatment information for Pancreatitis

5.9M

People Affected

150

Active Trials

472K

New Cases/Year

122K

Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

Endoscopic Retrograde Cholangiopancreatography (ERCP) with Sphincterotomy and Stone Removal

90% Effectiveness• 90% Confidence• 55% Safety• 7 trials• 30K participants

HIGH EvidenceExcellent Value

Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Time to Effect

immediate

Duration

one-time procedure

Response Rate

90%

Remission Rate

Number Needed to Treat (NNT)

Number Needed to Harm (NNH)

Common Side Effects:

Post-ERCP pancreatitis: 8%

Bleeding: 1.5%

Perforation: 0.5%

Annual Cost of Care

Drug Cost

$500

Monitoring

$1,000

Side Effects

$5,000

Total Annual

$6,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

ICER

$30,000/QALY

Cost per Responder

$7,222.22

Treatment Outcomes

Primary Outcomes

Serum Amylase500 U/L

-80% (-400 U/L)

Serum Lipase800 U/L

-85% (-680 U/L)

Total Bilirubin (in cases with obstructive jaundice)5.0 mg/dL

-70% (-3.5 mg/dL)

Abdominal Pain SeverityNumeric Rating Scale (NRS) pain: 8/10

-62.5% (-5 points)

Secondary Benefits

Recurrence Rate of Acute Pancreatitis (within 1 year)50% (of patients with recurrent biliary pancreatitis)

-80% (-40 percentage points)

Hospital Length of Stay7 days

-28.6% (-2 days)

C-reactive protein (CRP)150 mg/L

-70% (-105 mg/L)

Common Side Effects

Post-ERCP pancreatitis

+8%

Bleeding

+1.5%

Perforation

+0.5%

Clinical Trial Phases:

Phase 4

Pancreatic Enzyme Replacement Therapy (PERT)

85% Effectiveness• 90% Confidence• 85% Safety• 4 trials• 25K participants

HIGH EvidenceGood ValueDose: 25,000-80,000 lipase units per meal/snack

Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

85%

Remission Rate

Number Needed to Treat (NNT)

Common Side Effects:

Abdominal pain: 15%

Flatulence: 10%

Diarrhea: 7%

Annual Cost of Care

Drug Cost

$10,000

Monitoring

$300

Side Effects

$100

Total Annual

$10,400

Cost-Effectiveness

GOOD

QALYs Gained

0.2

ICER

$70,000/QALY

Cost per Responder

$12,235.29

Treatment Outcomes

Primary Outcomes

Fecal Fat Excretion (24-hour)25 g/24h

-70% (-17.5 g/24h)

Body Weight60 kg

+5% (+3 kg)

Abdominal Pain Score (0-10 NRS)7/10

-43% (-3 points)

Stool Frequency (episodes of steatorrhea per week)14 episodes/week

-71% (-10 episodes/week)

Secondary Benefits

Serum 25-hydroxyvitamin D20 ng/mL

+50% (+10 ng/mL)

Quality of Life (EQ-5D-5L index value)0.65

+23% (+0.15 points)

Serum Albumin3.2 g/dL

+19% (+0.6 g/dL)

Common Side Effects

Abdominal pain

+15%

Flatulence

+10%

Diarrhea

+7%

Clinical Trial Phases:

Phase 4

Intravenous Fluid Resuscitation (e.g., Lactated Ringer's)

85% Effectiveness• 90% Confidence• 85% Safety• 500 trials• 50K participants

HIGH EvidenceExcellent ValueDose: 5-10 mL/kg/hour initially, then titrated

Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Time to Effect

immediate

Duration

days to weeks

Response Rate

85%

Remission Rate

Common Side Effects:

Fluid overload: 7%

Electrolyte imbalance: 7%

Pulmonary edema: 2%

Annual Cost of Care

Drug Cost

$50

Monitoring

$1,000

Side Effects

$100

Total Annual

$1,150

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

Cost per Responder

$1,352.94

Treatment Outcomes

Efficacy Outcomes

Overall Effectiveness

+85%

Response Rate

+85%

Common Side Effects

Fluid overload

+7%

Electrolyte imbalance

+7%

Pulmonary edema

+2%

Early Enteral Nutrition (via nasogastric or nasojejunal tube)

80% Effectiveness• 85% Confidence• 85% Safety• 250 trials• 20K participants

HIGH EvidenceExcellent ValueDose: gradually advanced, 25-50 mL/hour initial

Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Time to Effect

days

Duration

days to weeks

Response Rate

75%

Remission Rate

Number Needed to Treat (NNT)

Common Side Effects:

Diarrhea: 15%

Abdominal distension: 7%

Tube displacement: 7%

Annual Cost of Care

Drug Cost

$500

Monitoring

$1,000

Side Effects

$100

Total Annual

$1,600

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

Cost per Responder

$2,133.33

Treatment Outcomes

Efficacy Outcomes

Overall Effectiveness

+80%

Response Rate

+75%

Common Side Effects

Diarrhea

+15%

Abdominal distension

+7%

Tube displacement

+7%

Opioid Analgesics (e.g., Hydromorphone)

75% Effectiveness• 90% Confidence• 45% Safety• 400 trials• 40K participants

HIGH EvidenceModerate ValueDose: 0.5-2 mg IV every 2-4 hours; 2-8 mg oral every 3-6 hours

Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Time to Effect

immediate (IV), 30-60 minutes (oral)

Duration

days to weeks (acute), long-term (chronic with caveats)

Response Rate

75%

Remission Rate

Number Needed to Treat (NNT)

2.5

Number Needed to Harm (NNH)

Common Side Effects:

Nausea: 25%

Constipation: 30%

Sedation: 20%

Respiratory depression: 3%

Addiction/Dependence (chronic use): 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$200

Side Effects

$1,000

Total Annual

$1,250

Cost-Effectiveness

MODERATE

QALYs Gained

0.1

Cost per Responder

$1,666.67

Treatment Outcomes

Efficacy Outcomes

Overall Effectiveness

+75%

Response Rate

+75%

Common Side Effects

Nausea

+25%

Constipation

+30%

Sedation

+20%

Clinical Trial Phases:

Phase 4