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Deep Brain Stimulation (DBS)
Treatment for Parkinson's disease
Typical Dosage: Programmable stimulation parameters
Effectiveness
88%
Safety Score
45%
Clinical Trials
336
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe
Treatment Details
Dosage Range
Programmable stimulation parameters
Time to Effect
Days to weeks (post-activation)
Treatment Duration
Lifetime (with battery replacement every 3-5 years)
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
30(Treat 30 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$6,000
Side Effect Mgmt:$500
Total Annual:$14,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$90,000/QALY
QALYs Gained
0.15
Outcome-Based Costs
Cost per Responder
$17,500
Comparison vs Optimal Medical Therapy
Cost Difference
+$18,000/year
More expensive
QALY Difference
+0.15 QALYs
Better outcomes
Dominance
No dominance
Deep Brain Stimulation (DBS) Outcomes
for Parkinson's disease
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+80%
Common Side Effects
Infection
+7%
Intracranial hemorrhage
+3%
Device-related complications
+10%
Speech/swallowing issues
+7%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
5 active trials recruiting for Deep Brain Stimulation (DBS) in Parkinson's disease
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
NCT02071134RECRUITING
1.5K participants
OBSERVATIONAL
Aliso Viejo, United States +83 more
Started: Mar 4, 2014
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
NCT06911229RECRUITINGNA
60 participants
INTERVENTIONAL
Gainesville, United States
Started: Aug 1, 2025
Coordinated Reset Deep Brain Stimulation for Parkinson's Disease
NCT07340073NOT YET RECRUITINGPHASE1
24 participants
INTERVENTIONAL
Started: Jul 1, 2026
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
NCT05557864RECRUITINGNA
24 participants
INTERVENTIONAL
Minneapolis, United States
Started: Aug 25, 2016
Sleep-specific DBS Therapy in Parkinson's Disease
NCT05962489RECRUITINGNA
64 participants
INTERVENTIONAL
Minneapolis, United States
Started: Jun 22, 2023
Completed Clinical Trials
11 completed trials for Deep Brain Stimulation (DBS) in Parkinson's disease
Deep Brain Stimulation for Parkinson's Disease Trial
NCT00053625COMPLETEDPHASE3
123 participants
INTERVENTIONAL
Atlanta, United States +1 more
Started: Jun 1, 1999
Effects of Deep Brain Stimulation (DBS) Frequency on Neural Synchrony
NCT02304848COMPLETEDNA
9 participants
INTERVENTIONAL
Stanford, United States
Started: Oct 1, 2012
Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS
NCT02549859COMPLETEDNA
11 participants
INTERVENTIONAL
Chicago, United States
Started: Aug 1, 2015
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
NCT01839396COMPLETEDNA
313 participants
INTERVENTIONAL
Phoenix, United States +21 more
Started: May 17, 2013
Clinical Outcomes of Deep Brain Stimulator (DBS) Electrodes Placed Using Intraoperative Computed Tomography (CT) and Frameless Stereotaxis
NCT01703598COMPLETEDNA
69 participants
INTERVENTIONAL
Portland, United States
Started: Sep 1, 2011
Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease
NCT04184791COMPLETEDNA
24 participants
INTERVENTIONAL
Great Neck, United States
Started: Jan 15, 2020
Uncovering an Electrical Biomarker for Freezing of Gait in Parkinson's Disease
NCT02548897COMPLETEDNA
5 participants
INTERVENTIONAL
Gainesville, United States
Started: Oct 1, 2015
Development and Validation of a Scale Measuring Preoperative Expectations in Parkinson's Disease
NCT04933513COMPLETED
22 participants
OBSERVATIONAL
Nancy, France
Started: Mar 30, 2022
INfusion VErsus STimulation in Parkinson's Disease
NCT02480803COMPLETEDPHASE4
51 participants
INTERVENTIONAL
Amsterdam, Netherlands
Started: Dec 19, 2014
CUSTOM-DBS: Current Steering to Optimize Deep Brain Stimulation
NCT01896115COMPLETEDNA
40 participants
INTERVENTIONAL
Valencia, United States +9 more
Started: Jun 1, 2013
Tandem DBS for Parkinson's Disease: A Pilot Study Utilizing STN/GPi + Hypothalamic Stimulation
NCT01563341COMPLETEDNA
5 participants
INTERVENTIONAL
Jacksonville, United States
Started: Apr 1, 2012
Showing 20 of 355 total trials