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Amitriptyline
Treatment for Peripheral Neuropathy
Typical Dosage: 10-150 mg daily
Effectiveness
70%
Safety Score
50%
Clinical Trials
25
Participants
35K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
10-150 mg daily
Time to Effect
2-4 weeks
Treatment Duration
lifetime
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$90
Monitoring:$300
Side Effect Mgmt:$200
Total Annual:$590
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$10,000/QALY
QALYs Gained
0.06
Outcome-Based Costs
Cost per Responder
$1,072.73
Cost per Remission
$4,916.67
Comparison vs Duloxetine
Cost Difference
$-10/year
Less expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Amitriptyline Outcomes
for Peripheral Neuropathy
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+55%
Remission Rate
+12%
Common Side Effects
Dry mouth
+40%
Sedation/Drowsiness
+30%
Constipation
+20%
Dizziness/Orthostatic hypotension
+15%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
3 active trials recruiting for Amitriptyline in Peripheral Neuropathy
Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)
NCT05593614ACTIVE NOT RECRUITINGPHASE2
276 participants
INTERVENTIONAL
Clermont, United States +42 more
Started: Feb 28, 2023
The Treatment of Painful Diabetic Neuropathy With Diet
NCT07509671RECRUITINGNA
40 participants
INTERVENTIONAL
Hendersonville, United States
Started: Apr 23, 2024
The Effectiveness of Ultra-Sound Guided Erector Spinae Block With Betamethasone for Management of Truncal Chronic Post Herpetic Neuralgia.
NCT07000409RECRUITINGNA
40 participants
INTERVENTIONAL
Cairo, Egypt
Started: May 1, 2025
Completed Clinical Trials
11 completed trials for Amitriptyline in Peripheral Neuropathy
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
NCT00370656COMPLETEDPHASE2, PHASE3
90 participants
INTERVENTIONAL
Bournemouth, United Kingdom +2 more
Started: Feb 1, 2007
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
NCT00000817COMPLETEDNA
260 participants
INTERVENTIONAL
San Francisco, United States +10 more
Started: Nov 1, 1994
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection
NCT00000793COMPLETEDPHASE2
240 participants
INTERVENTIONAL
Birmingham, United States +36 more
A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy
NCT00476151COMPLETEDPHASE2
226 participants
INTERVENTIONAL
New Delhi, India
Started: Jul 1, 2007
Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients
NCT00471445COMPLETEDPHASE3
462 participants
INTERVENTIONAL
Honolulu, United States +16 more
Started: Oct 1, 2007
Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
NCT00516503COMPLETEDPHASE3
208 participants
INTERVENTIONAL
Scottsdale, United States +164 more
Started: Feb 1, 2008
Local Anaesthetic Effects of Transcutaneous Amitriptyline
NCT00355277COMPLETEDPHASE1
16 participants
INTERVENTIONAL
Clermont-Ferrand, France
Started: Nov 1, 2005
Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain
NCT00266643COMPLETEDPHASE4
205 participants
INTERVENTIONAL
Phoenix, United States +19 more
Started: Dec 1, 2005
Sham Device, Pill Placebo or Treatment For Arm Pain
NCT00029497COMPLETEDPHASE2
240 participants
INTERVENTIONAL
Boston, United States +1 more
A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN)
NCT00475904COMPLETEDPHASE2
360 participants
INTERVENTIONAL
New Delhi, India
Started: Jul 1, 2007
Study to Evaluate the Interest of Qutenza in Patients With Head and Neck Cancer in Remission and With Sequelae Neuropathic Pain.
NCT04704453COMPLETEDPHASE2
13 participants
INTERVENTIONAL
Angers, France +3 more
Started: Apr 28, 2021
Showing 20 of 27 total trials