Booting Earth Optimization System
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Methotrexate
Treatment for Psoriasis
Typical Dosage: 7.5-25mg once weekly
Effectiveness
30%
Safety Score
30%
Clinical Trials
104
Participants
25K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
7.5-25mg once weekly
Time to Effect
6-12 weeks
Treatment Duration
long-term
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
99%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$1,100
Side Effect Mgmt:$300
Total Annual:$1,800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$15,000/QALY
QALYs Gained
0.6
Outcome-Based Costs
Cost per Responder
$5,143
Cost per Remission
$45,000
Methotrexate Outcomes
for Psoriasis
Efficacy Outcomes
Overall Effectiveness
+30%
Response Rate
+35%
Remission Rate
+4%
Common Side Effects
Nausea
+20%
Fatigue
+15%
Elevated liver enzymes
+10%
Stomatitis
+5%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
3 active trials recruiting for Methotrexate in Psoriasis
Microbiome and Clinical Response to Probiotics and Methotrexate in Early Psoriasis: a Pilot Study
NCT07169019RECRUITINGEARLY_PHASE1
24 participants
INTERVENTIONAL
Alexandria, Egypt
Started: Aug 1, 2025
Comparison Between Oral Methotrexate and Tofacitinib in Chronic Plaque Psoriasis
NCT07261306RECRUITINGEARLY_PHASE1
75 participants
INTERVENTIONAL
Lahore, Pakistan
Started: Aug 29, 2025
Methotrexate Versus Apremilast for Pruritus in Psoriasis
NCT07432386NOT YET RECRUITINGPHASE4
80 participants
INTERVENTIONAL
Rawalpindi, Pakistan
Started: May 14, 2026
Completed Clinical Trials
10 completed trials for Methotrexate in Psoriasis
Roflumilast Versus Methotrexate in Psoriasis
NCT05684744COMPLETEDPHASE2, PHASE3
30 participants
INTERVENTIONAL
Cairo, Egypt
Started: Jan 9, 2023
Dose Ranging Study to Compare the Efficacy and Safety of Methotrexate in Plaque Type Psoriasis
NCT01187264COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Chandigarh, India
Started: Aug 1, 2008
Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis
NCT03757364COMPLETED
32 participants
OBSERVATIONAL
Olsztyn, Poland
Started: Jan 7, 2018
Bioavailability in Patient With Psoriasis: Metoject Prefilled Pen
NCT02097173COMPLETEDPHASE1
35 participants
INTERVENTIONAL
San Antonio, United States
Started: May 1, 2013
A Safety and Efficacy Study of Ustekinumab in Patients With Plaque Psoriasis Who Have Had an Inadequate Response to Methotrexate
NCT01059773COMPLETEDPHASE4
490 participants
INTERVENTIONAL
Vienna, Austria +75 more
Started: Oct 1, 2009
The Effects of Infliximab Versus Methotrexate in the Treatment of Moderate to Severe Psoriasis (Study P04271AM2)(COMPLETED)
NCT00251641COMPLETEDPHASE3
868 participants
INTERVENTIONAL
Started: Sep 1, 2005
Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR Study
NCT02196701COMPLETEDPHASE3
46 participants
INTERVENTIONAL
Started: Aug 5, 2014
A Study Comparing the Safety and Efficacy of Risankizumab to Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis
NCT03219437COMPLETEDPHASE3
104 participants
INTERVENTIONAL
Curitiba, Brazil +10 more
Started: Jul 30, 2018
Comparison Study of Psoriasis Severity Assessment Tools
NCT02655705COMPLETEDPHASE4
34 participants
INTERVENTIONAL
Seongnam-si, South Korea
Started: Aug 1, 2014
Trial in Patients With Psoriasis Treated With Methotrexate Using an Optimized Treatment Schedule (METOP)
NCT02902861COMPLETEDPHASE3
120 participants
INTERVENTIONAL
Kiel, Germany
Started: Feb 1, 2013
Showing 20 of 116 total trials