Booting Earth Optimization System
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Exagamglogene autotemcel (Casgevy)
Treatment for Sickle cell disorders
Typical Dosage: Single infusion of modified cells after myeloablative conditioning
Effectiveness
93%
Safety Score
25%
Clinical Trials
7
Participants
150
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe
Treatment Details
Dosage Range
Single infusion of modified cells after myeloablative conditioning
Time to Effect
6-12 months for engraftment and recovery
Treatment Duration
Single procedure, but long recovery and follow-up
Evidence Quality
MODERATENumber Needed to Treat (NNT)
1(Treat 1 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
4(Treat 4 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$110,000
Monitoring:$15,000
Side Effect Mgmt:$5,000
Total Annual:$130,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POORICER
$4,500,000/QALY
QALYs Gained
18
Outcome-Based Costs
Cost per Responder
$141,304
Cost per Remission
$144,444
Comparison vs Standard medical management (e.g., hydroxyurea)
Cost Difference
+$55,000/year
More expensive
QALY Difference
+13.00 QALYs
Better outcomes
Dominance
No dominance
Exagamglogene autotemcel (Casgevy) Outcomes
for Sickle cell disorders
Efficacy Outcomes
Overall Effectiveness
+93%
Response Rate
+92%
Remission Rate
+90%
Common Side Effects
Myelosuppression/Febrile neutropenia (from conditioning)
+90%
Infection
+70%
Mucositis
+60%
Veno-occlusive disease
+10%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov