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Saline Nasal Irrigation
Treatment for Upper respiratory infections
Typical Dosage: 1-2 washes per nostril, 1-3 times daily
Effectiveness
60%
Safety Score
95%
Clinical Trials
11
Participants
5.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe
Treatment Details
Dosage Range
1-2 washes per nostril, 1-3 times daily
Time to Effect
Immediate
Treatment Duration
As needed, 3-7 days for nasal symptoms
Evidence Quality
MODERATENumber Needed to Treat (NNT)
7(Treat 7 patients to see 1 additional successful outcome)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$15
Monitoring:$600
Side Effect Mgmt:$0
Total Annual:$615
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.004
Outcome-Based Costs
Cost per Responder
$21.43
Saline Nasal Irrigation Outcomes
for Upper respiratory infections
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+70%
Common Side Effects
Nasal discomfort/burning
+8%
Ear fullness
+0.5%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
2 active trials recruiting for Saline Nasal Irrigation in Upper respiratory infections
Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT
NCT07598188NOT YET RECRUITINGNA
60 participants
INTERVENTIONAL
Islamabad, Pakistan
Started: Jul 10, 2026
A COMBINATION OF RECTAL INDOMETHACIN AND COLD WATER EXPOSURE OF THE AMPULLA AFTER ERCP IS SUPERIOR TO RECTAL INDOMETHACIN ALONE IN REDUCING THE INCIDENCE OF POST-ERCP PANCREATITIS -RCT
NCT07574970RECRUITING
150 participants
OBSERVATIONAL
Hyderabad, India
Started: Dec 1, 2025
Completed Clinical Trials
8 completed trials for Saline Nasal Irrigation in Upper respiratory infections
Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.
NCT02438579COMPLETEDNA
66 participants
INTERVENTIONAL
Edinburgh, United Kingdom
Started: Aug 1, 2014
Examination of the Effectiveness of Nasal Irrigation Techniques in Infants With Nasal Congestion
NCT06002594COMPLETEDNA
80 participants
INTERVENTIONAL
Istanbul, Turkey (Türkiye)
Started: Aug 15, 2019
Prevention With Healsea in Adults Against Respiratory Infection Study
NCT06613906COMPLETEDNA
198 participants
INTERVENTIONAL
Sofia, Bulgaria
Started: Nov 29, 2024
Testing the Efficacy in Adults With Cold of HEalsea Rescue*
NCT05819190COMPLETEDNA
200 participants
INTERVENTIONAL
Sofia, Bulgaria
Started: Dec 14, 2022
HEALSea Nasal Spray for Prevention of Infections in Children
NCT06582589COMPLETEDPHASE2, PHASE3
139 participants
INTERVENTIONAL
Dupnitsa, Bulgaria +7 more
Started: Nov 25, 2024
Pain Reduction Using Two Cold Irrigating Protocols in Teeth With Vital Pulps.
NCT03559127COMPLETEDNA
240 participants
INTERVENTIONAL
Tijuana, Mexico +2 more
Started: Mar 7, 2018
The Effect of Different Intraradicular Cryotherapy on Post-operative Pain and the Level of Substance P
NCT06106386COMPLETEDNA
135 participants
INTERVENTIONAL
Cairo, Egypt
Started: Jan 1, 2024
Coblation Tonsillotomy Versus Radiofrequency and Cold Knife Dissection Tonsillectomy
NCT06937762COMPLETEDNA
72 participants
INTERVENTIONAL
Kafrelsheikh, Egypt
Started: Apr 20, 2025