All33Pages1Tasks24Instruction Manual8

8 results for "clinical trials" in manual

I
Instruction Manual
manual.warondisease.org/knowledge/appendix/parameters-and-calculations / Overview

Methodology, Parameters, and Calculations

Parameter definitions, formulas, uncertainty ranges, and data sources.

I
Instruction Manual
manual.warondisease.org/knowledge/economics/1-pct-treaty-impact / Abstract

The 1% Treaty: Harnessing Greed to Eradicate Disease

6,650 diseases (95% CI: 5,700 diseases-8,242 diseases) have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years (95% CI: 324 years-712 years). Redirecting 1% of military spending scales capacity 12.3x (95% CI: 4.2x-61.4x), cutting the timeline to ~36 years (95% CI: 11.6 years-77.1 years) and preventing 10.7 billion deaths (95% CI: 7.4 billion deaths-16.2 billion deaths). At $0.00177 (95% CI: $0.000715-$0.00412)/DALY, 50.3kx (95% CI: 23.8kx-111.7kx) more cost-effective than the best existing interventions. Incentive Alignment Bonds make adoption politically viable.

I
Instruction Manual
manual.warondisease.org/knowledge/appendix/optimal-budget-generator-spec / Abstract

The Optimal Budget Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Goods Funding

The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.

I
Instruction Manual
manual.warondisease.org/knowledge/problem/fda-is-unsafe-and-ineffective / A Note on Blame

Your FDA Is Unsafe and Ineffective

A drug passes every safety test your species invented. It won't hurt you. Everyone agrees. You still can't have it for another 8.2 years (95% CI: 4.85 years-11.5 years). There is, however, no waiting list for dying. No one blocks that. The testing costs 44.1x (95% CI: 39.4x-89.1x) more than proven alternatives and excludes 86.1% of the patients who'll actually take it. For every 1 unit of harm prevented, the system creates 3,068 (95% CI: 2,878-3,125) through denied access. Here's how to fix it.

I
Instruction Manual
manual.warondisease.org/knowledge/appendix/dfda-impact-paper / Executive Summary

Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents

Only 15 diseases/year (95% CI: 8 diseases/year-30 diseases/year) get their first treatment each year. With 6,650 diseases (95% CI: 5,700 diseases-8,242 diseases) lacking effective treatments, the backlog would take 443 years (95% CI: 324 years-712 years) to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x (95% CI: 4.2x-61.4x), cutting that timeline from 443 years (95% CI: 324 years-712 years) to 36 years (95% CI: 11.6 years-77.1 years). The average untreated disease gets a treatment 212 years (95% CI: 135 years-355 years) earlier, saving 10.7 billion deaths (95% CI: 7.4 billion deaths-16.2 billion deaths) at $0.842 (95% CI: $0.242-$1.75) per year of healthy life saved.

I
Instruction Manual
manual.warondisease.org/knowledge/problem/genetic-slavery / How Hydrogen Learned to Worry (A 13.8 Billion Year Recap)

Genetic Slavery

Your government spends 604 (95% CI: 453-894) more on weapons than on curing disease, and you think that's a political problem. It's not. It's a hardware problem. You're running 200,000-year-old software optimized for hoarding rocks and fearing strangers, and you've given it nuclear weapons. This chapter is the owner's manual for the brain that's trying to kill you.

I
Instruction Manual
manual.warondisease.org/knowledge/problem/nih-fails-2-institute-health / A Tale of Two Trials

NIH Fails to Institute Health

A root cause failure analysis to show why the world's largest medical research institution only allocates 3.3% of its budget to testing which of the thousands of known-safe treatments actually work in humans. Oxford tested COVID treatments for $500 per patient and saved a million lives in 100 days. The NIH spent $1.6 billion and completed zero trials in four years.

I
Instruction Manual
manual.warondisease.org/knowledge/appendix/right-to-trial-fda-upgrade-act / TITLE I: SHORT TITLE; PURPOSE; FINDINGS; DEFINITIONS

Right to Trial & FDA Upgrade Act

Act to modernize medical research and treatment access through an open-source FDA.gov v2, giving patients the right to participate in trials.