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33 results for "clinical trials"

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Optimitron
/treaty / Learn

The 1% Treaty

1% of war budgets → clinical trials

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Instruction Manual
manual.warondisease.org/knowledge/appendix/parameters-and-calculations / Overview

Methodology, Parameters, and Calculations

Parameter definitions, formulas, uncertainty ranges, and data sources.

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Instruction Manual
manual.warondisease.org/knowledge/economics/1-pct-treaty-impact / Abstract

The 1% Treaty: Harnessing Greed to Eradicate Disease

6,650 diseases (95% CI: 5,700 diseases-8,242 diseases) have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years (95% CI: 324 years-712 years). Redirecting 1% of military spending scales capacity 12.3x (95% CI: 4.2x-61.4x), cutting the timeline to ~36 years (95% CI: 11.6 years-77.1 years) and preventing 10.7 billion deaths (95% CI: 7.4 billion deaths-16.2 billion deaths). At $0.00177 (95% CI: $0.000715-$0.00412)/DALY, 50.3kx (95% CI: 23.8kx-111.7kx) more cost-effective than the best existing interventions. Incentive Alignment Bonds make adoption politically viable.

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Instruction Manual
manual.warondisease.org/knowledge/appendix/optimal-budget-generator-spec / Abstract

The Optimal Budget Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Goods Funding

The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.

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Instruction Manual
manual.warondisease.org/knowledge/problem/fda-is-unsafe-and-ineffective / A Note on Blame

Your FDA Is Unsafe and Ineffective

A drug passes every safety test your species invented. It won't hurt you. Everyone agrees. You still can't have it for another 8.2 years (95% CI: 4.85 years-11.5 years). There is, however, no waiting list for dying. No one blocks that. The testing costs 44.1x (95% CI: 39.4x-89.1x) more than proven alternatives and excludes 86.1% of the patients who'll actually take it. For every 1 unit of harm prevented, the system creates 3,068 (95% CI: 2,878-3,125) through denied access. Here's how to fix it.

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Instruction Manual
manual.warondisease.org/knowledge/appendix/dfda-impact-paper / Executive Summary

Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents

Only 15 diseases/year (95% CI: 8 diseases/year-30 diseases/year) get their first treatment each year. With 6,650 diseases (95% CI: 5,700 diseases-8,242 diseases) lacking effective treatments, the backlog would take 443 years (95% CI: 324 years-712 years) to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x (95% CI: 4.2x-61.4x), cutting that timeline from 443 years (95% CI: 324 years-712 years) to 36 years (95% CI: 11.6 years-77.1 years). The average untreated disease gets a treatment 212 years (95% CI: 135 years-355 years) earlier, saving 10.7 billion deaths (95% CI: 7.4 billion deaths-16.2 billion deaths) at $0.842 (95% CI: $0.242-$1.75) per year of healthy life saved.

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Instruction Manual
manual.warondisease.org/knowledge/problem/genetic-slavery / How Hydrogen Learned to Worry (A 13.8 Billion Year Recap)

Genetic Slavery

Your government spends 604 (95% CI: 453-894) more on weapons than on curing disease, and you think that's a political problem. It's not. It's a hardware problem. You're running 200,000-year-old software optimized for hoarding rocks and fearing strangers, and you've given it nuclear weapons. This chapter is the owner's manual for the brain that's trying to kill you.

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Instruction Manual
manual.warondisease.org/knowledge/problem/nih-fails-2-institute-health / A Tale of Two Trials

NIH Fails to Institute Health

A root cause failure analysis to show why the world's largest medical research institution only allocates 3.3% of its budget to testing which of the thousands of known-safe treatments actually work in humans. Oxford tested COVID treatments for $500 per patient and saved a million lives in 100 days. The NIH spent $1.6 billion and completed zero trials in four years.

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Instruction Manual
manual.warondisease.org/knowledge/appendix/right-to-trial-fda-upgrade-act / TITLE I: SHORT TITLE; PURPOSE; FINDINGS; DEFINITIONS

Right to Trial & FDA Upgrade Act

Act to modernize medical research and treatment access through an open-source FDA.gov v2, giving patients the right to participate in trials.

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Task
/tasks/1-pct-treaty-signer-zw / Active / Governance / Assignee: Emmerson Mnangagwa

Sign the 1% Treaty

**Emmerson Mnangagwa** — Head of Government of Zimbabwe. One job: redirect 1% of Zimbabwe's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Emmerson Mnangagwa / Government of Zimbabwe

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Task
/tasks/1-pct-treaty-signer-zm / Active / Governance / Assignee: Edgar Lungu

Sign the 1% Treaty

**Edgar Lungu** — Head of Government of Zambia. One job: redirect 1% of Zambia's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Edgar Lungu / Government of Zambia

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Task
/tasks/1-pct-treaty-signer-za / Active / Governance / Assignee: Cyril Ramaphosa

Sign the 1% Treaty

**Cyril Ramaphosa** — Head of Government of South Africa. One job: redirect 1% of South Africa's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Cyril Ramaphosa / Government of South Africa

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Task
/tasks/1-pct-treaty-signer-ye / Active / Governance / Assignee: Salem Saleh bin Braik

Sign the 1% Treaty

**Salem Saleh bin Braik** — Head of Government of Yemen. One job: redirect 1% of Yemen's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Salem Saleh bin Braik / Government of Yemen

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Task
/tasks/1-pct-treaty-signer-ws / Active / Governance / Assignee: Fiamē Naomi Mataʻafa

Sign the 1% Treaty

**Fiamē Naomi Mataʻafa** — Head of Government of Samoa. One job: redirect 1% of Samoa's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Fiamē Naomi Mataʻafa / Government of Samoa

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Task
/tasks/1-pct-treaty-signer-vu / Active / Governance / Assignee: Bob Loughman

Sign the 1% Treaty

**Bob Loughman** — Head of Government of Vanuatu. One job: redirect 1% of Vanuatu's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Bob Loughman / Government of Vanuatu

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Task
/tasks/1-pct-treaty-signer-vn / Active / Governance / Assignee: Phạm Minh Chính

Sign the 1% Treaty

**Phạm Minh Chính** — Head of Government of Vietnam. One job: redirect 1% of Vietnam's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Phạm Minh Chính / Government of Vietnam

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Task
/tasks/1-pct-treaty-signer-ve / Active / Governance / Assignee: Nicolás Maduro

Sign the 1% Treaty

**Nicolás Maduro** — Head of State of Venezuela. One job: redirect 1% of Venezuela's military spending into pragmatic clinical trials. Overdue. Head of State Assigned to Nicolás Maduro / Government of Venezuela

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Task
/tasks/1-pct-treaty-signer-vc / Active / Governance / Assignee: Godwin Friday

Sign the 1% Treaty

**Godwin Friday** — Head of Government of Saint Vincent and the Grenadines. One job: redirect 1% of Saint Vincent and the Grenadines's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Godwin Friday / Government of Saint Vincent and the Grenadines

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Task
/tasks/1-pct-treaty-signer-va / Active / Governance / Assignee: Raffaella Petrini

Sign the 1% Treaty

**Raffaella Petrini** — Head of Government of Vatican City. One job: redirect 1% of Vatican City's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Raffaella Petrini / Government of Vatican City

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Task
/tasks/1-pct-treaty-signer-uz / Active / Governance / Assignee: Abdulla Aripov

Sign the 1% Treaty

**Abdulla Aripov** — Head of Government of Uzbekistan. One job: redirect 1% of Uzbekistan's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Abdulla Aripov / Government of Uzbekistan

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Task
/tasks/1-pct-treaty-signer-uy / Active / Governance / Assignee: Yamandú Orsi

Sign the 1% Treaty

**Yamandú Orsi** — Head of Government of Uruguay. One job: redirect 1% of Uruguay's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Yamandú Orsi / Government of Uruguay

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Task
/tasks/1-pct-treaty-signer-us / Active / Governance / Assignee: Donald Trump

Sign the 1% Treaty

**Donald Trump** — Head of Government of United States. One job: redirect 1% of United States's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Donald Trump / Government of United States

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Task
/tasks/1-pct-treaty-signer-ug / Active / Governance / Assignee: Robinah Nabbanja

Sign the 1% Treaty

**Robinah Nabbanja** — Head of Government of Uganda. One job: redirect 1% of Uganda's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Robinah Nabbanja / Government of Uganda

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Task
/tasks/1-pct-treaty-signer-ua / Active / Governance / Assignee: Yulia Svyrydenko

Sign the 1% Treaty

**Yulia Svyrydenko** — Head of Government of Ukraine. One job: redirect 1% of Ukraine's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Yulia Svyrydenko / Government of Ukraine

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Task
/tasks/1-pct-treaty-signer-tz / Active / Governance / Assignee: Samia Suluhu Hassan

Sign the 1% Treaty

**Samia Suluhu Hassan** — Head of Government of Tanzania. One job: redirect 1% of Tanzania's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Samia Suluhu Hassan / Government of Tanzania

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Task
/tasks/1-pct-treaty-signer-tw / Active / Governance / Assignee: Cho Jung-tai

Sign the 1% Treaty

**Cho Jung-tai** — Head of Government of Taiwan. One job: redirect 1% of Taiwan's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Cho Jung-tai / Government of Taiwan

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Task
/tasks/1-pct-treaty-signer-tv / Active / Governance / Assignee: Feleti Teo

Sign the 1% Treaty

**Feleti Teo** — Head of Government of Tuvalu. One job: redirect 1% of Tuvalu's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Feleti Teo / Government of Tuvalu

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Task
/tasks/1-pct-treaty-signer-tt / Active / Governance / Assignee: Kamla Persad-Bissessar

Sign the 1% Treaty

**Kamla Persad-Bissessar** — Head of Government of Trinidad and Tobago. One job: redirect 1% of Trinidad and Tobago's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Kamla Persad-Bissessar / Government of Trinidad and Tobago

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Task
/tasks/1-pct-treaty-signer-tr / Active / Governance / Assignee: Recep Tayyip Erdoğan

Sign the 1% Treaty

**Recep Tayyip Erdoğan** — President of Turkey. One job: redirect 1% of Turkey's military spending into pragmatic clinical trials. Overdue. President Assigned to Recep Tayyip Erdoğan / Government of Turkey

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Task
/tasks/1-pct-treaty-signer-to / Active / Governance / Assignee: Fatafehi Fakafānua, 8th Lord Fakafānua

Sign the 1% Treaty

**Fatafehi Fakafānua, 8th Lord Fakafānua** — Head of Government of Tonga. One job: redirect 1% of Tonga's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Fatafehi Fakafānua, 8th Lord Fakafānua / Government of Tonga

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Task
/tasks/1-pct-treaty-signer-tn / Active / Governance / Assignee: Sarra Zaafrani

Sign the 1% Treaty

**Sarra Zaafrani** — Head of Government of Tunisia. One job: redirect 1% of Tunisia's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Sarra Zaafrani / Government of Tunisia

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Task
/tasks/1-pct-treaty-signer-tm / Active / Governance / Assignee: Serdar Berdimuhamedow

Sign the 1% Treaty

**Serdar Berdimuhamedow** — Head of Government of Turkmenistan. One job: redirect 1% of Turkmenistan's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Serdar Berdimuhamedow / Government of Turkmenistan

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Task
/tasks/1-pct-treaty-signer-tl / Active / Governance / Assignee: Xanana Gusmão

Sign the 1% Treaty

**Xanana Gusmão** — Head of Government of Timor-Leste. One job: redirect 1% of Timor-Leste's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Xanana Gusmão / Government of Timor-Leste