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33 results for "clinical trials"
97% clinical trials, 3% overhead — the exact mirror of your NIH
Parameter definitions, formulas, uncertainty ranges, and data sources.
6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years (95% CI: 255 years-841 years). Redirecting 1% of military spending scales capacity 12.3x (95% CI: 4.92x-50.8x), cutting the timeline to ~36 years (95% CI: 8.15 years-106 years) and preventing 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths). At $0.00177 (95% CI: $0.000809-$0.00354)/DALY, 50.3kx (95% CI: 25.0kx-111.1kx) more cost-effective than the best existing interventions. Incentive Alignment Bonds make adoption politically viable.
The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two terminal general-welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.
A ready-to-load Google Ads campaign template for nonprofit partners running the 1% Treaty voter-acquisition channel through their existing Google Ad Grant.
A drug passes every safety test your species invented. It won't hurt you. Everyone agrees. You still can't have it for another 8.2 years (95% CI: 4.84 years-11.5 years). There is, however, no waiting list for dying. No one blocks that. The testing costs 44.1x (95% CI: 12.8x-210x) more than proven alternatives and excludes 86.1% of the patients who'll actually take it. For every 1 unit of harm prevented, the system creates 3,389 (95% CI: 1,811-5,734) through denied access. Here's how to fix it.
Only 15 diseases/year (95% CI: 8 diseases/year-30 diseases/year) get their first treatment each year. With 6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) lacking effective treatments, the backlog would take 443 years (95% CI: 255 years-841 years) to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x (95% CI: 4.92x-50.8x), cutting that timeline from 443 years (95% CI: 255 years-841 years) to 36 years (95% CI: 8.15 years-106 years). The average untreated disease gets a treatment 212 years (95% CI: 124 years-398 years) earlier, saving 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths) at $0.842 (95% CI: $0.264-$1.49) per year of healthy life saved.
Your government spends 604 (95% CI: 453-888) more on weapons than on curing disease, and you think that's a political problem. It's not. It's a hardware problem. You're running 200,000-year-old software optimized for hoarding rocks and fearing strangers, and you've given it nuclear weapons. This chapter is the owner's manual for the brain that's trying to kill you.
A root cause failure analysis to show why the world's largest medical research institution only allocates 3.3% of its budget to testing which of the thousands of known-safe treatments actually work in humans. Oxford tested COVID treatments for $500 per patient and saved a million lives in 100 days. The NIH spent $1.6 billion and completed zero trials in four years.
**Raffaella Petrini** — Head of Government of Holy See (Vatican City). One job: redirect 1% of Holy See (Vatican City)'s military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Raffaella Petrini / Government of Holy See (Vatican City)
**Cho Jung-tai** — Head of Government of Taiwan. One job: redirect 1% of Taiwan's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Cho Jung-tai / Government of Taiwan
**Daniel Risch** — Head of Government of Liechtenstein. One job: redirect 1% of Liechtenstein's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Daniel Risch / Government of Liechtenstein
**Feleti Teo** — Head of Government of Tuvalu. One job: redirect 1% of Tuvalu's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Feleti Teo / Government of Tuvalu
**Derog Gioura** — Head of Government of Nauru. One job: redirect 1% of Nauru's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Derog Gioura / Government of Nauru
**Hilda Heine** — Head of Government of Marshall Islands. One job: redirect 1% of Marshall Islands's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Hilda Heine / Government of Marshall Islands
**Surangel Whipps Jr.** — Head of Government of Palau. One job: redirect 1% of Palau's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Surangel Whipps Jr. / Government of Palau
**Wesley Simina** — Head of Government of Micronesia. One job: redirect 1% of Micronesia's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Wesley Simina / Government of Micronesia
**Taneti Maamau** — Head of Government of Kiribati. One job: redirect 1% of Kiribati's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Taneti Maamau / Government of Kiribati
**Fatafehi Fakafānua, 8th Lord Fakafānua** — Head of Government of Tonga. One job: redirect 1% of Tonga's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Fatafehi Fakafānua, 8th Lord Fakafānua / Government of Tonga
**Bob Loughman** — Head of Government of Vanuatu. One job: redirect 1% of Vanuatu's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Bob Loughman / Government of Vanuatu
**Roosevelt Skerrit** — Head of Government of Dominica. One job: redirect 1% of Dominica's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Roosevelt Skerrit / Government of Dominica
**Américo Ramos** — Head of Government of São Tomé & Príncipe. One job: redirect 1% of São Tomé & Príncipe's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Américo Ramos / Government of São Tomé & Príncipe
**Terrance Drew** — Head of Government of St. Kitts & Nevis. One job: redirect 1% of St. Kitts & Nevis's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Terrance Drew / Government of St. Kitts & Nevis
**Fiamē Naomi Mataʻafa** — Head of Government of Samoa. One job: redirect 1% of Samoa's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Fiamē Naomi Mataʻafa / Government of Samoa
**Godwin Friday** — Head of Government of Saint Vincent and the Grenadines. One job: redirect 1% of Saint Vincent and the Grenadines's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Godwin Friday / Government of Saint Vincent and the Grenadines
**Jeremiah Manele** — Head of Government of Solomon Islands. One job: redirect 1% of Solomon Islands's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Jeremiah Manele / Government of Solomon Islands
**Dickon Mitchell** — Head of Government of Grenada. One job: redirect 1% of Grenada's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Dickon Mitchell / Government of Grenada
**Denise Bronzetti** — Head of State of San Marino. One job: redirect 1% of San Marino's military spending into pragmatic clinical trials. Overdue. Head of State Assigned to Denise Bronzetti / Government of San Marino
**Gaston Browne** — Head of Government of Antigua & Barbuda. One job: redirect 1% of Antigua & Barbuda's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Gaston Browne / Government of Antigua & Barbuda
**Azali Assoumani** — Head of Government of Comoros. One job: redirect 1% of Comoros's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Azali Assoumani / Government of Comoros
**Alix Didier Fils-Aimé** — Head of Government of Haiti. One job: redirect 1% of Haiti's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Alix Didier Fils-Aimé / Government of Haiti
**Philip J. Pierre** — Head of Government of St. Lucia. One job: redirect 1% of St. Lucia's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Philip J. Pierre / Government of St. Lucia
**Xavier Espot Zamora** — Head of Government of Andorra. One job: redirect 1% of Andorra's military spending into pragmatic clinical trials. Overdue. Head of Government Assigned to Xavier Espot Zamora / Government of Andorra